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Protein Dynamic Landscape during Mouse Mammary Gland Development from Virgin to Pregnant, Lactating, and Involuting Stages

文献类型： 外文期刊

作者： Wang, Wenjing 1 ; Wang, Shunbo 1 ; Wang, Hao 1 ; Zheng, Enqin 1 ; Wu, Zhenfang 1 ; Li, Zicong 1 ;

作者机构： 1.South China Agr Univ, Natl Engn Res Ctr Breeding Swine Ind, Dept Anim Genet Breeding & Reprod,State Key Lab Sw, Guangdong Prov Key Lab Agroanim Genom & Mol Breed, Guangzhou 510642, Peoples R China

2.South China Agr Univ, Natl & Local Joint Engn Res Ctr Livestock & Poultr, Guangzhou 510642, Peoples R China

3.Guangdong Prov Lab Lingnan Modern Agr Sci & Techno, Guangzhou 510642, Peoples R China

关键词： development; mammary gland; mouse; DIA-based quantitativeproteomics; EGF

期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：6.1； 五年影响因子：6.3 ）

ISSN： 0021-8561

年卷期： 2024 年 72 卷 13 期

页码：

收录情况： SCI

摘要： The mammary gland undergoes significant physiological changes as it undergoes a transition from virgin to pregnancy, lactation, and involution. However, the dynamic role of proteins in regulating these processes during mouse mammary gland development has not been thoroughly explored. In this study, we collected mouse mammary gland tissues from mature virgins aged 8-10 weeks (V), day 16 of pregnancy (P16d), day 12 of lactation (L12d), day 1 of forced weaning (FW 1d), and day 3 of forced weaning (FW 3d) stages for analysis using DIA-based quantitative proteomics technology. A total of 3,312 proteins were identified, of which 843 were DAPs that were categorized into nine clusters based on their abundance changes across developmental stages. Notably, DAPs in cluster 2, which peaked at the L12d stage, were primarily associated with mammary gland development and lactation. The protein-protein interaction network revealed that the epidermal growth factor (EGF) was central to this cluster. Our study provides a comprehensive overview of the mouse mammary gland development proteome and identifies some important proteins, such as EGF, Janus kinase 1 (JAK1), and signal transducer and activator of transcription 6 (STAT6) that may serve as potential targets for future research to provide guidelines for a deeper understanding of the developmental biology of mammary glands.

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