Protein Dynamic Landscape during Mouse Mammary Gland Development from Virgin to Pregnant, Lactating, and Involuting Stages
文献类型： 外文期刊
作者： Wang, Wenjing 1 ; Wang, Shunbo 1 ; Wang, Hao 1 ; Zheng, Enqin 1 ; Wu, Zhenfang 1 ; Li, Zicong 1 ;
作者机构： 1.South China Agr Univ, Natl Engn Res Ctr Breeding Swine Ind, Dept Anim Genet Breeding & Reprod,State Key Lab Sw, Guangdong Prov Key Lab Agroanim Genom & Mol Breed, Guangzhou 510642, Peoples R China
2.South China Agr Univ, Natl & Local Joint Engn Res Ctr Livestock & Poultr, Guangzhou 510642, Peoples R China
3.Guangdong Prov Lab Lingnan Modern Agr Sci & Techno, Guangzhou 510642, Peoples R China
关键词： development; mammary gland; mouse; DIA-based quantitativeproteomics; EGF
期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：6.1； 五年影响因子：6.3 ）
ISSN： 0021-8561
年卷期： 2024 年 72 卷 13 期
页码：
收录情况： SCI
摘要： The mammary gland undergoes significant physiological changes as it undergoes a transition from virgin to pregnancy, lactation, and involution. However, the dynamic role of proteins in regulating these processes during mouse mammary gland development has not been thoroughly explored. In this study, we collected mouse mammary gland tissues from mature virgins aged 8-10 weeks (V), day 16 of pregnancy (P16d), day 12 of lactation (L12d), day 1 of forced weaning (FW 1d), and day 3 of forced weaning (FW 3d) stages for analysis using DIA-based quantitative proteomics technology. A total of 3,312 proteins were identified, of which 843 were DAPs that were categorized into nine clusters based on their abundance changes across developmental stages. Notably, DAPs in cluster 2, which peaked at the L12d stage, were primarily associated with mammary gland development and lactation. The protein-protein interaction network revealed that the epidermal growth factor (EGF) was central to this cluster. Our study provides a comprehensive overview of the mouse mammary gland development proteome and identifies some important proteins, such as EGF, Janus kinase 1 (JAK1), and signal transducer and activator of transcription 6 (STAT6) that may serve as potential targets for future research to provide guidelines for a deeper understanding of the developmental biology of mammary glands.
- 相关文献
作者其他论文 更多>>
-
Analysis of differential transcriptome expression reveals that ISG15 provides support for embryo development by promoting angiogenesis in porcine mesometrium
作者：Gan, Jianyu;Wang, Yongzhong;Zhang, Fan;Zang, Xupeng;Gu, Ting;Xu, Zheng;Li, Zicong;Cai, Gengyuan;Wu, Zhenfang;Hong, Linjun;Gan, Jianyu;Wang, Yongzhong;Zhang, Fan;Zang, Xupeng;Gu, Ting;Xu, Zheng;Li, Zicong;Cai, Gengyuan;Wu, Zhenfang;Hong, Linjun;Meng, Fanming;Wu, Zhenfang;Hong, Linjun
关键词：Pig; Mesometrium; Transcriptome; Interferon response; ISG15
-
GPCPD1 is regulated by METTL3/IGF2BP3 dependent m6A modification to affect pig muscle fiber type conversion
作者：Yang, Yuming;Xiao, Liyao;Huang, Huijun;Su, Jiawei;Hong, Linjun;Cai, Gengyuan;Li, Zicong;Gu, Ting;Yang, Yuming;Xiao, Liyao;Huang, Huijun;Su, Jiawei;Hong, Linjun;Cai, Gengyuan;Li, Zicong;Gu, Ting;Tan, Baohua;Xu, Weihua;Zhao, Yaolu;Dai, Lihe
关键词：GPCPD1; Pig; m 6 A; Myogenic differentiation; Muscle fiber type conversion
-
Genome-Wide Association Study Reveals Genetic Mechanisms Underlying Intersex and Aproctia in Large White Pigs
作者：Li, Yajun;Shi, Jiaxin;Yang, Yingshan;Ruan, Donglin;Wu, Jie;Lin, Danyang;Liao, Zihao;Hong, Xinrun;Zhou, Fuchen;Liu, Langqing;Yang, Jie;Zheng, Enqin;Wu, Zhenfang;Cai, Gengyuan;Zhang, Zebin;Li, Yajun;Shi, Jiaxin;Yang, Yingshan;Ruan, Donglin;Wu, Jie;Lin, Danyang;Liao, Zihao;Hong, Xinrun;Zhou, Fuchen;Liu, Langqing;Yang, Jie;Zheng, Enqin;Wu, Zhenfang;Cai, Gengyuan;Zhang, Zebin;Wu, Jie;Yang, Ming;Wu, Zhenfang;Cai, Gengyuan;Wu, Zhenfang;Cai, Gengyuan
关键词：intersex; aproctia; chip data; imputed data; mixed linear models; genome-wide association studies
-
A deep learning-based approach for fully automated segmentation and quantitative analysis of muscle fibers in pig skeletal muscle
作者：Yao, Zekai;Li, Hao;Li, Xinxin;Li, Jianhao;Luo, Yizhi;Meng, Fanming;Yao, Zekai;Zheng, Enqin;Yang, Jie;Li, Hao;Li, Xinxin;Wang, Ting;Fan, Zhenfei;Zhan, Yuexin;Yang, Yingshan;Wu, Zhenfang;Yao, Zekai;Zheng, Enqin;Yang, Jie;Li, Hao;Li, Xinxin;Wang, Ting;Fan, Zhenfei;Zhan, Yuexin;Yang, Yingshan;Wu, Zhenfang;Wo, Jingjie;Yin, Ling;Wu, Zhenfang;Luo, Yizhi;Zheng, Enqin;Yang, Jie;Wu, Zhenfang
关键词：Pigs; Skeletal muscle; Deep learning; Image segmentation; Quantitative analysis
-
Multi-omic characterization of allele-specific regulatory variation in hybrid pigs
作者：Quan, Jianping;Wang, Xingwang;Cai, Gengyuan;Ding, Rongrong;Zhuang, Zhanwei;Zhou, Shenping;Ruan, Donglin;Wu, Jiajin;Zheng, Enqin;Zhang, Zebin;Liu, Langqing;Meng, Fanming;Wu, Jie;Xu, Cineng;Qiu, Yibin;Wang, Shiyuan;Lin, Meng;Li, Shaoyun;Ye, Yong;Zhou, Fuchen;Lin, Danyang;Li, Xuehua;Deng, Shaoxiong;Zhang, Yuling;Yao, Zekai;Yang, Yingshan;Liu, Yiyi;Zhan, Yuexin;Zhang, Jiaming;Ma, Fucai;Yang, Jifei;Chen, Qiaoer;Yang, Jisheng;Gu, Ting;Huang, Sixiu;Xu, Zheng;Li, Zicong;Yang, Jie;Wu, Zhenfang;Quan, Jianping;Ding, Rongrong;Tan, Suxu;Huang, Wen;Quan, Jianping;Cai, Gengyuan;Wu, Jiajin;Zheng, Enqin;Zhang, Zebin;Liu, Langqing;Lin, Meng;Huang, Sixiu;Yang, Jie;Quan, Jianping;Ding, Rongrong;Ye, Jian;Dong, Linsong;Wu, Zhenfang;Yang, Ming;Gao, Xin;Liu, Zhihong;Yang, Ming;Ding, Rongrong;Ye, Jian;Dong, Linsong;Wu, Zhenfang;Wang, Xingwang;Cai, Gengyuan;Zhuang, Zhanwei;Zhou, Shenping;Ruan, Donglin;Wu, Jiajin;Zheng, Enqin;Zhang, Zebin;Liu, Langqing;Wu, Jie;Xu, Cineng;Qiu, Yibin;Wang, Shiyuan;Li, Shaoyun;Ye, Yong;Zhou, Fuchen;Lin, Danyang;Li, Xuehua;Deng, Shaoxiong;Zhang, Yuling;Yao, Zekai;Yang, Yingshan;Liu, Yiyi;Zhan, Yuexin;Zhang, Jiaming;Ma, Fucai;Yang, Jifei;Gu, Ting;Xu, Zheng;Li, Zicong;Yang, Jie;Meng, Fanming
关键词：
-
Melatonergic Signaling Sustains Food Allergy Through FcεRI Recycling
作者：Wang, Youxia;Zhang, Xinmei;Ren, Wenkai;Wang, Hao;Hung, Ifen;Liu, Chunxue;Hung, Ifen;Ge, Liangpeng;Wang, Hao
关键词：
-
DIA-based quantitative proteomic analysis of porcine endometrium in the peri-implantation phase
作者：Zhou, Chen;Wang, Yongzhong;He, Simin;Lin, Shifei;Cheng, Jie;Hu, Qun;Gu, Ting;Cai, Gengyuan;Li, Zicong;Wu, Zhenfang;Hong, Linjun;Zhou, Chen;Wang, Yongzhong;He, Simin;Lin, Shifei;Cheng, Jie;Hu, Qun;Gu, Ting;Cai, Gengyuan;Li, Zicong;Wu, Zhenfang;Hong, Linjun;Zhou, Chen;Wang, Yongzhong;He, Simin;Lin, Shifei;Cheng, Jie;Hu, Qun;Cai, Gengyuan;Li, Zicong;Wu, Zhenfang;Hong, Linjun;Meng, Fanming;Wu, Zhenfang;Wu, Zhenfang;Hong, Linjun
关键词：DIA-based quantitative proteomics; Yorkshire; Endometrium; Peri-implantation; FGL2
