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Plasma Metabolomics Reveals Pathogenesis of Retained Placenta in Dairy Cows

文献类型： 外文期刊

作者： Li, Yuqiong 1 ; Zhao, Zhengwei 1 ; Yu, Yang 1 ; Liang, Xiaojun 1 ; Wang, Shengyi 2 ; Wang, Lei 2 ; Cui, Dongan 2 ; Huang, 1 ;

作者机构： 1.Ningxia Acad Agr & Forestry Sci, Lab Inst Anim Sci, Yinchuan, Ningxia, Peoples R China

2.Chinese Acad Agr Sci, Lanzhou Inst Husb & Pharmaceut Sci, Engn & Technol Res Ctr Tradit Chinese Vet Med Gan, Lanzhou, Peoples R China

3.Southwest Med Univ, Affiliated Hosp, Academician Expert Workstn Sichuan Prov, Luzhou, Peoples R China

关键词： retained placenta; dairy cow; metabolomics; biomarker; pathogenesis

期刊名称：FRONTIERS IN VETERINARY SCIENCE （ 影响因子：3.412； 五年影响因子：3.588 ）

ISSN：

年卷期： 2021 年 8 卷

页码：

收录情况： SCI

摘要： The complex etiology and pathogenesis of retained placenta (RP) bring huge challenges for researchers and clinical veterinarians in investigating the pathogenesis and treatment schedule. This study aims to investigate the pathogenesis of RP in dairy cows by plasma metabolomics. As subjects, 10 dairy cows with RP and 10 healthy dairy cows were enrolled according to strict enrollment criteria. Imbalanced antioxidant capacity, reduced Th1/Th2 cytokine ratio, and deregulation of total bilirubin (T-bil), alkaline phosphatase (ALP), and reproductive hormones were shown in dairy cows with RP by detecting biochemical indicators, oxidation and antioxidant markers, and cytokines in serum. Plasma metabolites were detected and analyzed by a liquid chromatography-mass spectrometry (LC-MS) system coupled with multivariate statistical analysis software. A total of 23 potential biomarkers were uncovered in the plasma of dairy cows with RP. The metabolic pathways involved in these potential biomarkers are interconnected, and the conversion, utilization, and excretion of nitrogen were disturbed in dairy cows with RP. Moreover, these potential biomarkers are involved in the regulation of antioxidant capacity, inflammation, and autocrine or paracrine hormone. All of these findings suggest that an imbalance of these potential biomarkers might be responsible for the imbalanced antioxidant capacity, reduced Th1/Th2 cytokine ratio, and deregulation of reproductive hormones in dairy cows with RP. The regulation of metabolic pathways involved in these potential biomarkers represents a promising therapeutic strategy for RP.

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