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Modified Huangqi Shengmai Yin enhances ruminal microbiome and metabolites activity in dairy cows with subclinical mastitis

文献类型： 外文期刊

作者： Zhang, Chenyibo 1 ; Zhang, Baoling 1 ; Li, Yuqiong 2 ; Kastelic, John P. 3 ; Li, Xiaoping 1 ; Tong, Xiaofang 1 ; Yao, A. 4 ; Xu, Chuang 1 ; Han, Bo 1 ; Gao, Jian 1 ;

作者机构： 1.China Agr Univ, Coll Vet Med, Dept Clin Vet Med, Beijing, Peoples R China

2.Ningxia Acad Agr & Forestry Sci, Inst Anim Sci, Yinchuan, Peoples R China

3.Univ Calgary, Fac Vet Med, Calgary, AB, Canada

4.Anim Hlth Supervis Inst, Lincang, Peoples R China

关键词： subclinical bovine mastitis; Huangqi Shengmai Yin; microbiome structure; metabolites activity; dairy cows

期刊名称：FRONTIERS IN VETERINARY SCIENCE （ 影响因子：2.9； 五年影响因子：3.3 ）

ISSN：

年卷期： 2025 年 12 卷

页码：

收录情况： SCI

摘要： Introduction Bovine mastitis, especially subclinical mastitis (SCM), with minimal clinical signs, is detrimental due to its resistance to treatment, recurrence, and substantial economic impact on global dairy industry. The modified form of Huangqi Shengmai Yin (HSY), classical traditional herbal medicine renowned for its effects in antimicrobial and circulatory-enhancing and thus beneficial for subclinical mastitis, has been developed for treatment attempt of SCM, yet its therapeutic effect and mechanism remains unclear. This study aims to investigate the therapeutic effects of mHSY on SCM in cows, and elucidate its potential therapeutic mechanism.Methods In this study, mHSY was given orally to cows with SCM. After a 3-day treatment regimen, the therapeutic effects were evaluated. 16S diversity sequencing and metabolomics were used to elucidate the therapeutic mechanism of HSY.Results The SCM was significantly alleviated after the 3-day treatment with HSY. In cows infected with SCM, there were significant alterations in rumen fluid microbiota, particularly proportions of Enterobacter, Desulfovibrio, and Flavonifractor, implying a pivotal role for these bacteria in SCM. Furthermore, the therapeutic potential of HSY is linked to improving the proportion of beneficial bacteria (e.g., Succinivibrionaceae_UCG-001) and re-establishing a balanced ruminal bacterial profile. Modulation of fatty acid and amino acid metabolism, as evidenced by changes in metabolite profiles, is a critical aspect of SCM and can be markedly ameliorated with mHSY administration.Conclusion mHSY shows significant inhibitory effects on SCM, which may be attributed to regulating ruminal microbiota and metabolic pathways in vivo.

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