Prevalence, genomic characteristics, and pathogenicity of fowl adenovirus 2 in Southern China
文献类型： 外文期刊
作者： Zhang, Junqin 1 ; Xie, Zimin 1 ; Pan, Yanlin 1 ; Chen, Zuoxin 1 ; Huang, Yunzhen 1 ; Li, Linlin 1 ; Dong, Jiawen 1 ; Xiang, Yong 1 ; Zhai, Qi 1 ; Sun, Minhua 1 ; Li, Xingying 6 ; Huang, Shujian 5 ; Liao, Ming 1 ;
作者机构： 1.Minist Agr & Rural Affairs, Guangdong Acad Agr Sci, Inst Anim Hlth, Key Lab prevent & control Avian fluenza & Other Ma, Guangzhou, Guangdong, Peoples R China
2.Key Lab Livestock Dis Prevent & Treatment Guangdon, Guangzhou, Guangdong, Peoples R China
3.South China Agr Univ, Guangzhou, Peoples R China
4.Zhongkai Univ Agr & Engn, Guangzhou, Peoples R China
5.Foshan Univ, Coll Life Sci & Engn, Foshan, Peoples R China
6.Guangdong VETCELL Biotech Co Ltd, Foshan, Peoples R China
关键词： fowl adenovirus 2; prevalence; complete genome; recombination; pathogenicity
期刊名称：POULTRY SCIENCE （ 影响因子：4.4； 五年影响因子：4.4 ）
ISSN： 0032-5791
年卷期： 2024 年 103 卷 1 期
页码：
收录情况： SCI
摘要： In recent years, the occurrence of fowl adenovirus 2 (FAdV-2) has been on the rise in China, posing a significant threat to the poultry industry. This study aimed to investigate the epidemiology, phylogenetic relationship, genomic characteristics, and pathogenicity of FAdV-2. The epidemiological analysis revealed the detection of multiple FAdV serotypes, including FAdV-1, FAdV-2, FAdV-3, FAdV-4, FAdV-8a, FAdV-8b, and FAdV-11 serotypes. Among them, FAdV-2 exhibited the highest proportion, accounting for 21.05% (8/38). The complete genomes of these 8 FAdV-2 strains were sequenced. Genetic evolution analysis indicated that these FAdV-2 strains formed a separate branch within the FAdV-D group, sharing 94.60 to 97.90% nucleotide similarity with the reference FAdV-2 and FAdV-11 strains. Notably, the recombination analysis revealed that 5 out of the 8 FAdV-2 strains, exhibited recombination events between FAdV-2 and FAdV-11. The recombination regions involved Hexon, Fiber, ORF19 genes and 30 end. Furthermore, pathogenicity experiments demonstrated that recombinant FAdV-2 XX strain is capable of inducing mortality rate of 66.70% and causing more severe hepatitis hydropericardium syndrome (HHS) in 6-wk-old specific-pathogen-free chickens. These findings contribute to our under-standing of the prevalence, genomic characteristics, and the pathogenicity of FAdV-2, providing foundations for FAdV-2 vaccine development.
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