The Discovery of Oxathiapiprolin as a Potential Agent for the Control of Litchi Downy Blight Caused by Peronophythora litchii and the Study of Its Mechanism of Action
文献类型： 外文期刊
作者： Cheng, Sirui 1 ; Tao, Kezhu 2 ; Lv, Xin 3 ; Lai, Zhenduo 2 ; Lv, Yi 2 ; Wang, Zhixin 2 ; Chen, Qinghe 1 ;
作者机构： 1.Hainan Univ, Sanya Inst Breeding & Multiplicat, Sch Breeding & Multiplicat, Sanya 572025, Peoples R China
2.Hainan Univ, Sch Trop Agr & Forestry, Key Lab Green Prevent & Control Trop Dis & Pests, Minist Educ, Haikou 570228, Peoples R China
3.Fujian Acad Agr Sci, Inst Agr Qual Stand & Testing Technol, Fuzhou 350003, Peoples R China
关键词： oxathiapiprolin; Peronophythora litchii; plasmamembrane integrity; lipid metabolism; autophagy
期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：6.2； 五年影响因子：6.4 ）
ISSN： 0021-8561
年卷期： 2025 年 73 卷 1 期
页码：
收录情况： SCI
摘要： Oxathiapiprolin, a novel fungicide targeting oxysterol-binding proteins (OSBP), has proven to be effective against various oomycete diseases, but its effects on pathogens remain underexplored. In this study, we demonstrated that oxathiapiprolin inhibits mycelium growth, sporangium production, zoospore release, and oospore production in Peronophythora litchii, with 50% effective concentrations ranging from 0.000153 to 0.011681 mu g mL-1. Additionally, in vivo tests confirmed its efficacy in controlling litchi downy blight. Our study demonstrated that oxathiapiprolin disrupts cellular ultrastructure and plasma membrane integrity, affects stress sensitivity, inhibits sterol transport, increases autophagy levels, reduces lipid droplet content, and induces lipid metabolism disorders. Gene expression analysis revealed that oxathiapiprolin affects the expression of PlORP1 (ORP1 gene of P. litchii), with docking simulations further confirming its interaction with the PlORP1 (ORP1 protein of P. litchii) protein. Ultimately, this cascade of events led to pathogen death. This paper reveals the antioomycete mechanism of oxathiapiprolin against P. litchii.
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