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Determination of Methylene Blue and Its Metabolite Residues in Aquatic Products by High-Performance Liquid Chromatography-Tandem Mass Spectrometry

文献类型： 外文期刊

作者： Zhang, Xuan 1 ; Hui, Yunhua 1 ; Fang, Changling 1 ; Wang, Yuan 1 ; Han, Feng 1 ; Lou, Xiaoyi 1 ; Fodjo, Essy Kouadio 3 ;

作者机构： 1.Chinese Acad Fishery Sci, East China Sea Fisheries Res Inst, Shanghai 200090, Peoples R China

2.Chinese Acad Fishery Sci, Key Lab East China, Sea Fisheries Res Inst, Shanghai 200090, Peoples R China

3.Univ Felix Houphouet Boigny, Phys Chem Lab, UFR SSMT, 22 BP 582, Abidjan, Cote Ivoire

关键词： high-performance liquid chromatography-tandem mass spectrometry; methylene blue; disinfectant; aquatic products

期刊名称：MOLECULES （ 影响因子：4.412； 五年影响因子：4.588 ）

ISSN：

年卷期： 2021 年 26 卷 16 期

页码：

收录情况： SCI

摘要： A sensitive and reliable method was developed to determine methylene blue (MB) and its metabolite residues, including azure A (AZA), azure B (AZB), and azure C (AZC) in aquatic products by HPLC-MS/MS. The samples were extracted by acetonitrile and cleaned up by alumina-neutral (ALN) cartridges. The analytes were separated on a Sunfire C18 column (150 mm x 2.1 mm, 5 mu m). The method was validated according to the European criteria of Commission Decision 2002/657/CE. Good linearity between 1-500 mu g/L was obtained with correlation coefficients (R-2) greater than 0.99. The limit of quantification (LOQ) was 1.0 mu g/kg. The average recoveries at three levels of each compound (1, 5, and 10 mu g/kg) were demonstrated to be in the range of 71.8-97.5%, with relative standard deviations (RSDs) from 1.05% to 8.63%. This method was suitable for the detection of methylene blue and its metabolite residues in aquatic products.

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