文献类型： 外文期刊
作者： Yang, Ying 1 ; Li, Yiming 1 ; Du, Xinglin 3 ; Liu, Zhiquan 5 ; Zhu, Chenxi 2 ; Mao, Weiping 2 ; Liu, Guoxing 1 ; Jiang, Qichen 1 ;
作者机构： 1.Freshwater Fisheries Res Inst Jiangsu Prov, Nanjing 210017, Peoples R China
2.Nanjing Normal Univ, Sch Life Sci, Inst Biochem & Biol Prod, Nanjing 210046, Peoples R China
3.East China Normal Univ, Sch Life Sci, Shanghai 200241, Peoples R China
4.Chinese Acad Fisheries Sci, Fishery Machinery & Instrument Res Inst, Shanghai 200092, Peoples R China
5.Hangzhou Normal Univ, Sch Life & Environm Sci, Hangzhou 311121, Zhejiang, Peoples R China
6.Hangzhou Normal Univ, Sch Engn, Hangzhou 310018, Zhejiang, Peoples R China
7.Freshwater Fisheries Res Inst Jiangsu Prov, Low Temp Germplasm Bank Important Econ Fish Jiangs, Nanjing 210017, Peoples R China
期刊名称：ACS OMEGA （ 影响因子：4.1； 五年影响因子：4.0 ）
ISSN： 2470-1343
年卷期： 2023 年 8 卷 20 期
页码：
收录情况： SCI
摘要： Quercetin is a flavonoid widely found in food and traditional herbs. In this study, we evaluated the anti-aging effects of quercetin on Simocephalus vetulus (S. vetulus) by assessing lifespan and growth parameters and analyzed the differentially expressed proteins and crucial pathways associated with quercetin activity using proteomics. The results demonstrated that, at a concentration of 1 mg/L, quercetin significantly prolonged the average and maximal lifespans of S. vetulus and increased the net reproduction rate slightly. The proteomics-based analysis revealed 156 differently expressed proteins, with 84 being significantly upregulated and 72 significantly downregulated. The protein functions were identified as being associated with glycometabolism, energy metabolism, and sphingolipid metabolism pathways, and the key enzyme activity and related gene expression, such that of AMPK, supported the importance of these pathways in the anti-aging activity of quercetin. In addition, quercetin was found to regulate the anti-aging-related proteins Lamin A and Klotho directly. Our results increased the understanding of quercetin's antiaging effects.
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