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Vimentin rearrangement by phosphorylation is beneficial for porcine reproductive and respiratory syndrome virus replication in vitro

文献类型： 外文期刊

作者： Zheng, Xin-Xian 1 ; Li, Rui 2 ; Qiao, Songlin 2 ; Chen, Xin-Xin 2 ; Zhang, Longxiang 1 ; Lu, Qingxia 2 ; Xing, Guangxu 2 ;

作者机构： 1.Northwest A&F Univ, Coll Vet Med, Yangling 712100, Shaanxi, Peoples R China

2.Henan Acad Agr Sci, Henan Prov Key Lab Anim Immunol, Minist Agr, Key Lab Anim Immunol, 116 Huayuan Rd, Zhengzhou 450002, Henan, Peoples R China

3.Henan Agr Univ, Coll Vet Med, 63 Nongye Rd, Zhengzhou 450002, Henan, Peoples R China

关键词： PRRSV; Replication; Vimentin; Rearrangement; CaMKII gamma

期刊名称：VETERINARY MICROBIOLOGY （ 影响因子：3.293； 五年影响因子：3.599 ）

ISSN： 0378-1135

年卷期： 2021 年 259 卷

页码：

收录情况： SCI

摘要： Vimentin, a member of intermediate filaments, has been documented to be involved in viral infections. Despite several studies focusing on its involvement in porcine reproductive and respiratory syndrome virus (PRRSV) infection, the detailed mechanisms by which vimentin takes effect remain to be fully elucidated. In the present study, we identified a previously unrecognized role of vimentin rearrangement in PRRSV replication. We monitored that PRRSV infection induced vimentin reorganization during post-entry stage, which was beneficial for viral replication. In detail, the serine residue of vimentin was phosphorylated at position 38 (Ser38) by calcium calmodulin-dependent protein kinase II gamma (CaMKII gamma), and vimentin filaments reorganized into cage-like structures enwrapping PRRSV replication complex (RC) at the perinuclear location. Taken together, these results expand the knowledge of PRRSV replication, and provide novel targets for prevention and control of PRRSV.

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