Engineering Escherichia coli Nissle 1917 as a microbial chassis for therapeutic and industrial applications
文献类型： 外文期刊
作者： Yu, Mingjing 1 ; Hu, Shilong 1 ; Tang, Biao 2 ; Yang, Hua 2 ; Sun, Dongchang 1 ;
作者机构： 1.Zhejiang Univ Technol, Coll Biotechnol & Bioengn, Hangzhou 310014, Zhejiang, Peoples R China
2.Zhejiang Acad Agr Sci, Inst Qual & Stand Agroprod, Hangzhou 310021, Zhejiang, Peoples R China
关键词： Escherichia coli Nissle 1917; Living therapeutics; CRISPR-Cas; Light-controlled gene expression; 'Suicide' systems; Minicells; Bacterial ghosts
期刊名称：BIOTECHNOLOGY ADVANCES （ 影响因子：16.0； 五年影响因子：16.8 ）
ISSN： 0734-9750
年卷期： 2023 年 67 卷
页码：
收录情况： SCI
摘要： Genetically engineered microbes, especially Escherichia coli, have been widely used in the biosynthesis of proteins and metabolites for medical and industrial applications. As a traditional probiotic with a well-established safety record, E. coli Nissle 1917 (EcN) has recently emerged as a microbial chassis for generating living therapeutics, drug delivery vehicles, and microbial platforms for industrial production. Despite the availability of genetic tools for engineering laboratory E. coli K-12 and B strains, new genetic engineering systems are still greatly needed to expand the application range of EcN. In this review, we have summarized the latest progress in the development of genetic engineering systems in EcN, as well as their applications in the biosynthesis and delivery of valuable small molecules and biomacromolecules of medical and/or industrial interest, followed by a glimpse of how this rapidly growing field will evolve in the future.
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