文献类型： 外文期刊
作者： Zhang, Fan 1 ; Wang, Wenzhang 1 ; Siedlak, Sandra L. 1 ; Liu, Yingchao 2 ; Liu, Jun 3 ; Jiang, Keji 5 ; Perry, George; 1 ;
作者机构： 1.Case Western Reserve Univ, Dept Pathol, Cleveland, OH 44106 USA
2.Shandong Univ, Shandong Prov Hosp, Dept Neurosurg, Jinan 250100, Peoples R China
3.Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Dept Neurol, Shanghai 200030, Peoples R China
4.Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Inst Neurol, Shanghai 200030, Peoples R China
5.Chinese Acad Fishery Sci, East China Sea Fisheries Res Inst, Shanghai, Peoples R China
6.Univ Texas San Antonio, Coll Sci, San Antonio, TX USA
关键词： amyotrophic lateral sclerosis;Miro1;mitochondrial transport;SOD1;TDP-43;glutamate excitotoxicity;neurodegeneration
期刊名称：FRONTIERS IN AGING NEUROSCIENCE （ 影响因子：5.75； 五年影响因子：5.913 ）
ISSN： 1663-4365
年卷期： 2015 年 7 卷
页码：
收录情况： SCI
摘要： Proper transportation of mitochondria to sites with high energy demands is critical for neuronal function and survival. Impaired mitochondrial movement has been repeatedly reported in motor neurons of amyotrophic lateral sclerosis (ALS) patients and indicated as an important mechanism contributing to motor neuron degeneration in ALS. Miro1, a RhoGTPase also referred to as Rhot1, is a key regulator of mitochondrial movement linking mitochondria and motor proteins. In this study, we investigated whether the expression of Miro1 was altered in ALS patients and ALS animal models. Immunoblot analysis revealed that Miro1 was significantly reduced in the spinal cord tissue of ALS patients. Consistently, the decreased expression of Miro1 was also noted only in the spinal cord, and not in the brain tissue of transgenic mice expressing ALS-associated SOD1 G93A or TDP-43 M337V. Glutamate excitotoxicity is one of the major pathophysiological mechanisms implicated in the pathogenesis of ALS, and we found that excessive glutamate challenge lead to significant reduction of Miro1 expression in spinal cord motor neurons both in vitro and in mice. Taken together, these findings show Miro1 deficiency in ALS patients and ALS animal models and suggest glutamate excitotoxicity as a likely cause of Miro1 deficiency.
- 相关文献
作者其他论文 更多>>
-
Comparative analysis of modeling methods and prediction accuracy for Japanese sardine habitat under three climate scenarios with differing greenhouse emission pathways
作者：Sun, Yuyan;Xiang, Delong;Wang, Jianhua;Jiang, Keji;Zhu, Hanji;Huang, SiSi;Zhang, Famou;Li, Yang;Zhang, Heng;Sun, Yuyan;Xiang, Delong;Jiang, Keji;Huang, SiSi;Zhang, Heng;Sun, Yuyan;Xiang, Delong;Jiang, Keji;Huang, SiSi;Zhang, Famou;Zhang, Heng;Wang, Jianhua;Zhu, Hanji;Li, Yang
关键词：Japanese sardine; Species distribution models (SDMs); Climate change; Spatial resolution; Species presence data points
-
A positive-sense single-stranded RNA virus acquired a negative-sense open reading frame through recombination
作者：Dong, Xuan;Zhang, Fan;Wang, Yiting;Li, Xuan;Zhou, Chengyan;Wang, Guohao;Huang, Jie;Dong, Xuan;Zhang, Fan;Wang, Yiting;Li, Xuan;Zhou, Chengyan;Wang, Guohao;Huang, Jie;Dong, Xuan;Zhang, Fan;Wang, Yiting;Li, Xuan;Zhou, Chengyan;Wang, Guohao;Huang, Jie;Li, Cixiu;Tian, Zhongshuai;Shi, Weifeng;Gao, Jing;Zhou, Hu;Sui, Liying;Nauwynck, Hans;Sorgeloos, Patrick;Holmes, Edward C.;Shi, Weifeng
关键词：
-
Dietary Astragalus Polysaccharides Can Improve the Immune Capacity and Reproductive Performance of the Lined Seahorse (Hippocampus erectus)
作者：Li, Siping;Liu, Xin;Lin, Tingting;Ren, Yuanhao;Zhang, Dong;Jiang, Keji;Li, Siping;Lin, Tingting;Liu, Xin
关键词：
Astragalus polysaccharides; immune capacity; juveniles and broodstocks; reproductive performance; seahorseHippocampus erectus -
Comparative analysis of phytoplankton community structure and stability in the Arabian Sea and Bay of Bengal using eDNA metabarcoding
作者：Li, Changwen;Xiao, Ge;Ai, Tongxi;Tang, Fenghua;Ju, Jianfeng;Yang, Shenglong;Gao, Lei;Ma, Lingbo;Fan, Wei;Zhao, Ming;Zheng, Hanfeng;Jiang, Keji;Li, Changwen;Ai, Tongxi;Ju, Jianfeng;Long, Han;Pi, Yan
关键词：eDNA; AS; BB; Phytoplankton; Diversity; Stability
-
The Effect of Corner Structure on the Optimisation of Fishable Flow Field in Aquaculture Tanks
作者：Zhang, Fan;Cui, Mingchao;Liu, Huang;Zhang, Chen;Zhang, Fan;Zhang, Chen
关键词：aquaculture vessel; corner ratio; fishability; effluent effect; eddy strength
-
Spatio-temporal variability of fishing habitat suitability to tuna purse seine fleet in the Western and Central Pacific Ocean
作者：Yang, Shenglong;Wang, Lijun;Zhang, Shengmao;Yu, Linlin;Zhang, Heng;Wang, Fei;Wu, Yumei;Wu, Zuli;Wang, Wei;Shi, Jiayu;Jiang, Keji;Fan, Wei;Yang, Shenglong;Zhang, Shengmao;Zhang, Heng;Wang, Fei;Wu, Yumei;Wu, Zuli;Jiang, Keji;Fan, Wei;Wang, Lijun;Shi, Jiayu;Fei, Yingjie;Yu, Linlin;Wang, Wei
关键词：Automatic identification system; Tuna purse seine fleet; Fishing habitat suitability; Satellite remote sensing data
-
Cryopreservation of Goldlined seabream Rhabdosargus sarba (Forsskal, 1775) sperm: CASA observation and enzyme activity evaluation
作者：Pan, Jin-Min;Zhu, Ke-Cheng;Liu, Jun;Guo, Hua-Yang;Liu, Bao-Suo;Zhang, Nan;Xian, Lin;Zhang, Dian-Chang;Zhu, Ke-Cheng;Liu, Bao-Suo;Zhang, Nan;Xian, Lin;Sun, Jin-Hui;Zhang, Dian-Chang;Zhu, Ke-Cheng;Guo, Hua-Yang;Liu, Bao-Suo;Zhang, Nan;Xian, Lin;Zhang, Dian-Chang;Pan, Jin-Min;Sun, Jin-Hui;Zhang, Dian-Chang
关键词：Sperm; Cryopreservation; CASA; Goldlined seabream; Enzyme activity
