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Gas and light: triggers of c-di-GMP-mediated regulation

文献类型： 外文期刊

作者： Yu, Zhaoqing 1 ; Zhang, Wei 1 ; Yang, He 1 ; Chou, Shan-Ho 1 ; Galperin, Michael Y. 4 ; He, Jin 1 ;

作者机构： 1.Huazhong Agr Univ, Coll Life Sci & Technol, Natl Key Lab Agr Microbiol, 1 Shizishan St, Wuhan 430070, Hubei, Peoples R China

2.Huazhong Agr Univ, Coll Life Sci & Technol, Hubei Hongshan Lab, 1 Shizishan St, Wuhan 430070, Hubei, Peoples R China

3.Jiangsu Acad Agr Sci, Inst Agroprod Proc, 50 Zhongling St, Nanjing 210014, Jiangsu, Peoples R China

4.NIH, Natl Ctr Biotechnol Informat, Natl Lib Med, 8600 Rockville Pike, Bethesda, MD 20894 USA

关键词： c-di-GMP; diguanylate cyclase; c-di-GMP-specific phosphodiesterase; sensory domains; NO sensors; photoreceptors

期刊名称：FEMS MICROBIOLOGY REVIEWS （ 影响因子：11.3； 五年影响因子：17.7 ）

ISSN： 0168-6445

年卷期： 2023 年 47 卷 4 期

页码：

收录情况： SCI

摘要： The widespread bacterial second messenger c-di-GMP is responsible for regulating many important physiological functions such as biofilm formation, motility, cell differentiation, and virulence. The synthesis and degradation of c-di-GMP in bacterial cells depend, respectively, on diguanylate cyclases and c-di-GMP-specific phosphodiesterases. Since c-di-GMP metabolic enzymes (CMEs) are often fused to sensory domains, their activities are likely controlled by environmental signals, thereby altering cellular c-di-GMP levels and regulating bacterial adaptive behaviors. Previous studies on c-di-GMP-mediated regulation mainly focused on downstream signaling pathways, including the identification of CMEs, cellular c-di-GMP receptors, and c-di-GMP-regulated processes. The mechanisms of CME regulation by upstream signaling modules received less attention, resulting in a limited understanding of the c-di-GMP regulatory networks. We review here the diversity of sensory domains related to bacterial CME regulation. We specifically discuss those domains that are capable of sensing gaseous or light signals and the mechanisms they use for regulating cellular c-di-GMP levels. It is hoped that this review would help refine the complete c-di-GMP regulatory networks and improve our understanding of bacterial behaviors in changing environments. In practical terms, this may eventually provide a way to control c-di-GMP-mediated bacterial biofilm formation and pathogenesis in general. The authors review the diversity of sensory domains related to the bacterial CME regulation and specifically discuss those domains that are capable of sensing gaseous or light signals and the mechanisms they use for regulating cellular c-di-GMP levels.

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