The antioxidant methyl gallate inhibits fungal growth and deoxynivalenol production in Fusarium graminearum
文献类型： 外文期刊
作者： Liu, Xin 1 ; Fang, Xin 1 ; Wang, Shuang 1 ; Wu, Deliang 1 ; Gao, Tao 1 ; Lee, Yin-Won 1 ; Mohamed, Sherif Ramzy 4 ; Ji, Fang 1 ; Xu, Jianhong 1 ; Shi, Jianrong 1 ;
作者机构： 1.Jiangsu Acad Agr Sci, Jiangsu Key Lab Food Qual & Safety,Key Lab Agro P, State Key Lab Cultivat Base,Minist Agr & Rural Af, Minist Sci & Technol,Key Lab Control Technol & St, Nanjing 210014, Jiangsu, Peoples R China
2.Jiangsu Univ, Sch Food & Biol Engn, Zhenjiang 212013, Jiangsu, Peoples R China
3.Seoul Natl Univ, Sch Agr Biotechnol, Seoul 08826, South Korea
4.Natl Res Ctr Egypt, Dept Food Toxicol & Contaminant, Giza 12411, Egypt
关键词： Fusarium graminearum; Antioxidant methyl gallate; Deoxynivalenol production; Mechanism of action
期刊名称：FOOD PRODUCTION PROCESSING AND NUTRITION （ 影响因子：4.7； 五年影响因子：5.0 ）
ISSN：
年卷期： 2021 年 3 卷 1 期
页码：
收录情况： SCI
摘要： Production of the Fusarium toxin deoxynivalenol (DON) is associated with oxidative stress and has been indicated to be part of an adaptive response to oxidative stress in the important wheat fungus Fusarium graminearum. In this study, we found that the antioxidant methyl gallate (MG) displays inhibitory effects against mycelial growth, conidial formation and germination, and DON biosynthesis in F. graminearum in a dose-dependent manner. Treatment with 0.05% (w/v) MG resulted in an abnormal swollen conidial morphology. The expression of the TRI genes involved in DON biosynthesis was significantly reduced, and the induction of Tri1-GFP green fluorescence signals in the spherical and crescent-shaped toxisomes was abolished in the MG-treated mycelium. RNA-Seq analysis of MG-treated F. graminearum showed that 0.5% (w/v) MG inhibited DON production by possibly altering membrane functions and oxidoreductase activities. Coupled with the observations that MG treatment decreases catalase, POD and SOD activity in F. graminearum. The results of this study indicated that MG displays antifungal activity against DON production by modulating its oxidative response. Taken together, the current study revealed the potential of MG in inhibiting mycotoxins in F. graminearum.
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