文献类型： 外文期刊

作者： Xia, Donghua ¹ ; Qiu, Wen ² ; Wang, Xianxian ³ ; Liu, Junying ¹ ;

作者机构： 1.Nanchang Univ, Engn Res Ctr Biomass Convers, State Key Lab Food Sci & Technol, Nanchang 330047, Jiangxi, Peoples R China

2.Shanghai Acad Agr Sci, Ecoenvironm Protect Res Inst, Shanghai 201403, Peoples R China

3.Karlsruhe Inst Technol, Inst Toxicol & Genet, D-76344 Eggenstein Leopoldshafen, Germany

4.Univ Limerick, Bernal Inst, Pharmaceut Mfg Technol Ctr PMTC, Limerick V94T9PX, Ireland

关键词： pharmaceuticals; polyunsaturated fatty acids; polysaccharides; astaxanthin; beta-glucan; immune activation

期刊名称：MARINE DRUGS （ 影响因子：6.085； 五年影响因子：6.044 ）

ISSN：

年卷期： 2021 年 19 卷 12 期

页码：

收录情况： SCI

摘要： Microalgal cells serve as solar-powered factories that produce pharmaceuticals, recombinant proteins (vaccines and drugs), and valuable natural byproducts that possess medicinal properties. The main advantages of microalgae as cell factories can be summarized as follows: they are fueled by photosynthesis, are carbon dioxide-neutral, have rapid growth rates, are robust, have low-cost cultivation, are easily scalable, pose no risk of human pathogenic contamination, and their valuable natural byproducts can be further processed. Despite their potential, there are many technical hurdles that need to be overcome before the commercial production of microalgal pharmaceuticals, and extensive studies regarding their impact on human health must still be conducted and the results evaluated. Clearly, much work remains to be done before microalgae can be used in the large-scale commercial production of pharmaceuticals. This review focuses on recent advancements in microalgal biotechnology and its future perspectives.