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Difference in muscle metabolism caused by metabolism disorder of rainbow trout liver exposed to ammonia stress

文献类型： 外文期刊

作者： Wu, Yiwen 1 ; Xia, Yuting 1 ; Hu, Ao 1 ; Xiong, Guangquan 1 ; Wu, Wenjin 1 ; Shi, Liu 1 ; Chen, Lang 1 ; Guo, Xiaojia 1 ; Qiao, Yu 1 ; Chunsheng, Liu 2 ; Yin, Tao 3 ; Wang, Lan 1 ; Chen, Sheng 1 ;

作者机构： 1.Hubei Acad Agr Sci, Inst Agroprod Proc & Nucl Agr Technol, Key Lab Agr Prod Cold Chain Logist, Minist Agr & Rural Affairs, Wuhan 430064, Peoples R China

2.China Univ Geosci, Sch Environm Studies, Wuhan 430074, Peoples R China

3.Huazhong Agr Univ, Coll Food Sci & Technol, Wuhan 430070, Peoples R China

4.Hubei Univ Technol, Sch Bioengn & Food Sci, Wuhan 430068, Peoples R China

关键词： Oncorhynchus mykiss; Stress time; Muscle quality; Liver toxicity; Multi-omics analysis

期刊名称：SCIENCE OF THE TOTAL ENVIRONMENT （ 影响因子：9.8； 五年影响因子：9.6 ）

ISSN： 0048-9697

年卷期： 2024 年 924 卷

页码：

收录情况： SCI

摘要： Ammonia pollution is an important environmental stress factors in water eutrophication. The intrinsic effects of ammonia stress on liver toxicity and muscle quality of rainbow trout were still unclear. In this study, we focused on investigating difference in muscle metabolism caused by metabolism disorder of rainbow trout liver at exposure times of 0, 3, 6, 9 h at 30 mg/L concentrations. Liver transcriptomic analysis revealed that short-term (3 h) ammonia stress inhibited carbohydrate metabolism and glycerophospholipid production but long-term (9 h) ammonia stress inhibited the biosynthesis and degradation of fatty acids, activated pyrimidine metabolism and mismatch repair, lead to DNA strand breakage and cell death, and ultimately caused liver damage. Metabolomic analysis of muscle revealed that ammonia stress promoted the reaction of glutamic acid and ammonia to synthesize glutamine to alleviate ammonia toxicity, and long-term (9 h) ammonia stress inhibited urea cycle, hindering the alleviation of ammonia toxicity. Moreover, it accelerated the consumption of flavor amino acids such as arginine and aspartic acid, and increased the accumulation of bitter substances (xanthine) and odorous substances (histamine). These findings provide valuable insights into the potential risks and hazards of ammonia in eutrophic water bodies subject to rainbow trout.

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