Incorporating genome-wide and transcriptome-wide association studies to identify genetic elements of longissimus dorsi muscle in Huaxi cattle
文献类型： 外文期刊
作者： Liang, Mang 1 ; An, Bingxing 1 ; Deng, Tianyu 1 ; Du, Lili 1 ; Li, Keanning 1 ; Cao, Sheng 1 ; Du, Yueying 1 ; Xu, Lingyang 1 ; Zhang, Lupei 1 ; Gao, Xue 1 ; Cao, Yang 2 ; Zhao, Yuming 2 ; Li, Junya 1 ; Gao, Huijiang 1 ;
作者机构： 1.Chinese Acad Agr Sci, Inst Anim Sci, Beijing, Peoples R China
2.Jilin Acad Agr Sci, Changchun, Peoples R China
关键词： longissimus dorsi muscle; GWAS; TWAS; FCT; Huaxi cattle
期刊名称：FRONTIERS IN GENETICS （ 影响因子：3.7； 五年影响因子：4.3 ）
ISSN：
年卷期： 2023 年 13 卷
页码：
收录情况： SCI
摘要： Locating the genetic variation of important livestock and poultry economic traits is essential for genetic improvement in breeding programs. Identifying the candidate genes for the productive ability of Huaxi cattle was one crucial element for practical breeding. Based on the genotype and phenotype data of 1,478 individuals and the RNA-seq data of 120 individuals contained in 1,478 individuals, we implemented genome-wide association studies (GWAS), transcriptome-wide association studies (TWAS), and Fisher's combined test (FCT) to identify the candidate genes for the carcass trait, the weight of longissimus dorsi muscle (LDM). The results indicated that GWAS, TWAS, and FCT identified seven candidate genes for LDM altogether: PENK was located by GWAS and FCT, PPAT was located by TWAS and FCT, and XKR4, MTMR3, FGFRL1, DHRS4, and LAP3 were only located by one of the methods. After functional analysis of these candidate genes and referring to the reported studies, we found that they were mainly functional in the progress of the development of the body and the growth of muscle cells. Combining advanced breeding techniques such as gene editing with our study will significantly accelerate the genetic improvement for the future breeding of Huaxi cattle.
- 相关文献
作者其他论文 更多>>
-
Novel perspectives on autophagy-oxidative stress-inflammation axis in the orchestration of adipogenesis
作者：Hong, Chun;Li, Xinming;Huang, Qiuyan;Li, Baohong;Xin, Haiyun;Hu, Bin;Meng, Fanming;Li, Jianhao;Wang, Sutian;Zhang, Kunli;Huang, Qiuyan;Hu, Chuanhuo;Zhu, Xiangxing;Tang, Dongsheng;Hu, Chuanhuo;Tao, Chenyu;Cao, Yang;Wang, Hai;Deng, Bo;Wang, Sutian
关键词：adipogenesis; autophagy; inflammation; oxidative stress; immune responses
-
The comparison of meat yield, quality, and flavor between small-tailed Han sheep and two crossbred sheep and the verification of related candidate genes
作者：Xiao, Cheng;Liu, Yu;Zhao, Wenjun;Liang, Yingjia;Cui, Chao;Yang, Shaoying;Fang, WenWen;Miao, Lisheng;Yuan, Zhiyu;Zhai, Bo;Zhao, Zhongli;Zhang, Lichun;Ma, Huihai;Jin, Haiguo;Cao, Yang;Xiao, Cheng;Xiao, Cheng;Zhao, Wenjun;Lin, Zihan
关键词：small-tailed Han sheep; crossbred sheep; meat yield; quality; volatile compound; PDK4 gene; TMEM273 gene
-
MED4 gene positively affects preadipocyte differentiation in Chinese red steppe cattle
作者：Wei, Minghong;Xiao, Cheng;Wu, Jian;Qin, Lihong;Liu, Hongliang;Cao, Yang;Zhao, Yumin;Xiao, Cheng;Wu, Jian;Qin, Lihong;Liu, Hongliang;Zhao, Yumin
关键词：Chinese red steppe cattle; MED4; PPAR gamma; Predipocyte differentiation; Lipid metabolism; Meat quality trait
-
RNA-Seq Analysis Identifies Differentially Expressed Genes in the Longissimus dorsi of Wagyu and Chinese Red Steppe Cattle
作者：Li, Guanghui;Yang, Runjun;Lu, Xin;Liu, Yue;He, Wei;Li, Yue;Yu, Haibin;Zhao, Zhihui;Fang, Xibi;Yu, Haibin;Zhao, Zhihui;Qin, Lihong;Cao, Yang
关键词：beef cattle; RNA sequencing; differentially expressed genes; meat quality traits; fat metabolism
-
Melatonin Protects the Apoptosis of Sheep Granulosa Cells by Suppressing Oxidative Stress via MAP3K8 and FOS Pathway
作者：Zhai, Bo;Li, Xu;Zhao, Zhongli;Cao, Yang;Liu, Xinxin;Liu, Zheng;Ma, Huihai;Lu, Wenfa
关键词：melatonin; apoptosis; sheep; granulosa cells; oxidative stress
-
Transcript variants of long-chain acyl-CoA synthase 1 have distinct roles in sheep lipid metabolism
作者：Cao, Yang;Yu, Yongsheng;Zhang, Lichun;Liu, Yu;Jin, Haiguo;Liu, Lixiang;Cao, Yang;Zheng, Kaizhi;Wang, Sutian
关键词：ACSL1; transcript variants; sheep; APA; lipid metabolism
-
Transcriptome profile analysis identifies candidate genes of feed utilization in Dorper and Small Tail Han crossbred sheep
作者：Xiao, Cheng;Liang, Yi Fan;Liu, Jian Qiang;Jin, Hai Guo;Cao, Yang;Liang, Yi Fan;Ma, Hui Hai;Wang, Chun Xin;Xiao, Cheng;Liang, Yi Fan;Liu, Jian Qiang;Ma, Hui Hai;Wang, Chun Xin;Jin, Hai Guo;Cao, Yang
关键词：Candidate genes; Feed utilization; Feed conversion ratio; Transcriptome sequencing; Sheep
