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Cytpchrome P450 CYP4G68 Is Associated with Imidacloprid and Thiamethoxam Resistance in Field Whitefly, Bemisia tabaci (Hemiptera: Gennadius)

文献类型： 外文期刊

作者： Liang, Jinjin 1 ; Yang, Jing 2 ; Hu, Jinyu 2 ; Fu, Buli 2 ; Gong, Peipan 2 ; Du, Tianhua 2 ; Xue, Hu 2 ; Wei, Xuegao 2 ; Liu, Shaonan 1 ; Huang, Mingjiao 1 ; Yin, Cheng 2 ; Ji, Yao 1 ; He, Chao 2 ; Xie, Wen 2 ; Wang, Ran 5 ; Yang, Xin 2 ; Zhang, Youjun 1 ;

作者机构： 1.Hunan Agr Univ, Coll Plant Protect, Changsha 410125, Peoples R China

2.Chinese Acad Agr Sci, Inst Vegetables & Flowers, Dept Plant Protect, Beijing 100081, Peoples R China

3.Chinese Acad Trop Agr Sci, Minist Agr & Rural Affairs, Key Lab Integrated Pest Management Trop Crops, Environm & Plant Protect Inst, Haikou 571101, Hainan, Peoples R China

4.Chinese Acad Agr Sci, Natl Res Inst Breeding Hainan, Sanya 572024, Peoples R China

5.Beijing Acad Agr & Forestry Sci, Inst Plant & Environm Protect, Beijing 100097, Peoples R China

关键词： cytochrome P450s; Bemisia tabaci; neonicotinoid resistance; sustainable pest control

期刊名称：AGRICULTURE-BASEL （ 影响因子：3.408； 五年影响因子：3.459 ）

ISSN：

年卷期： 2022 年 12 卷 4 期

页码：

收录情况： SCI

摘要： The superfamily cytochrome P450s is involved in the evolution of insecticide resistance. However, whether CYP4G68, a differentially expressed gene identified from our transcriptomics analysis, confers resistance to the world's heavily used insecticide class neonicotinoids is unknown. Hence, we explored the role of CYP4G68 in conferring imidacloprid and thiamethoxam resistance in Bemisia tabaci. The species B. tabaci MED developed low-to-high resistance to imidacloprid and thiamethoxam. Exposure to imidacloprid and thiamethoxam significantly increased the expression of CYP4G68. Moreover, quantitative real-time PCR analysis demonstrated that CYP4G68 was remarkably overexpressed in imidacloprid-resistant and thiamethoxam-resistant strains compared to susceptible strains. Further correlation analysis showed that CYP4G68 expression was significantly positively correlated with the associated resistance level in various strains of B. tabaci. These results suggest that the enhanced expression of CYP4G68 appears to mediate imidacloprid and thiamethoxam resistance in B. tabaci. Additionally, silencing CYP4G68 via RNA interference strongly increased the susceptibility of B. tabaci MED to imidacloprid and thiamethoxam. Collectively, this work revealed that CYP4G68 plays a vital role in imidacloprid and thiamethoxam resistance in B. tabaci MED. These findings will not only advance our understanding of the role of P450s in insecticide resistance but also provide a great potential target for the sustainable control of destructive insect pests such as whiteflies.

  • 相关文献

[1]Cytpchrome P450 CYP4G68 Is Associated with Imidacloprid and Thiamethoxam Resistance in Field Whitefly, Bemisia tabaci (Hemiptera: Gennadius). Liang, Jinjin,Liu, Shaonan,Huang, Mingjiao,Ji, Yao,Zhang, Youjun,Liang, Jinjin,Yang, Jing,Hu, Jinyu,Fu, Buli,Gong, Peipan,Du, Tianhua,Xue, Hu,Wei, Xuegao,Liu, Shaonan,Huang, Mingjiao,Yin, Cheng,Ji, Yao,He, Chao,Xie, Wen,Yang, Xin,Fu, Buli,Xie, Wen,Yang, Xin,Wang, Ran. 2022

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