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The Antioxidant Guaiacol Exerts Fungicidal Activity Against Fungal Growth and Deoxynivalenol Production in Fusarium graminearum

文献类型： 外文期刊

作者： Gao, Tao 1 ; Zhang, Yao 5 ; Shi, Jianrong 1 ; Mohamed, Sherif Ramzy 7 ; Xu, Jianhong 1 ; Liu, Xin 1 ;

作者机构： 1.Minist Sci & Technol, Jiangsu Acad Agr Sci, Inst Food Safety & Nutr, Jiangsu Key Lab Food Qual,Safety State Key Lab Cu, Nanjing, Peoples R China

2.Minist Agr Rural Affairs, Jiangsu Acad Agr Sci, Inst Food Safety & Nutr, Lab Control Technol & Standard Agroprod Safety, Nanjing, Peoples R China

3.Minist Agr & Rural Affairs, Jiangsu Acad Agr Sci, Inst Food Safety & Nutr, Key Lab Agro Product Safety Risk Evaluat Nanjing, Nanjing, Peoples R China

4.Jiangsu Acad Agr Sci, Collaborat Innovat Ctr Modern Grain Circulat & Sa, Inst Food Safety & Nutr, Nanjing, Peoples R China

5.Jiangsu Ocean Univ, Sch Food Sci & Engn, Lianyungang, Peoples R China

6.Jiangsu Univ, Sch Food & Biol Engn, Zhenjiang, Jiangsu, Peoples R China

7.Natl Res Ctr Egypt, Dept Food Toxicol & Contaminant, Giza, Egypt

关键词： Fusarium graminearum; guaiacol; intracellular Ca2+; deoxynivalenol; antioxidant

期刊名称：FRONTIERS IN MICROBIOLOGY （ 影响因子：6.064； 五年影响因子：6.843 ）

ISSN：

年卷期： 2021 年 12 卷

页码：

收录情况： SCI

摘要： The main component of creosote obtained from dry wood distillation-guaiacol-is a natural antioxidant that has been widely used in pharmaceutical and food preservation applications. However, the antifungal mechanism of guaiacol against phytopathogens remains unclear. In this study, we found that guaiacol exerts inhibitory effects against mycelial growth, conidial formation and germination, and deoxynivalenol (DON) biosynthesis in Fusarium graminearum in a dose-dependent manner. The median effective concentration (EC50) value of guaiacol for the standard F. graminearum strain PH-1 was 1.838 mM. Guaiacol strongly inhibited conidial production and germination. The antifungal effects of guaiacol may be attributed to its capability to cause damage to the cell membrane by disrupting Ca2+ transport channels. In addition, the decreased malondialdehyde (MDA) levels and catalase (CAT), peroxidase (POD), and superoxide dismutase (SOD) activity by guaiacol treatment indicate that guaiacol displays activity against DON production by modulating the oxidative response in F. graminearum. Taken together, this study revealed the potentials of antioxidant in inhibiting mycotoxins in F. graminearum.

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