Peroxisome Proliferator-Activated Receptor Signaling-Mediated 13-S-Hydroxyoctadecenoic Acid Is Involved in Lipid Metabolic Disorder and Oxidative Stress in the Liver of Freshwater Drum, Aplodinotus grunniens
文献类型： 外文期刊
作者： Xue, Miaomiao 1 ; Xu, Pao 1 ; Wen, Haibo 1 ; Chen, Jianxiang 1 ; Wang, Qingyong 1 ; He, Jiyan 1 ; He, Changchang 1 ; Kong, Changxin 1 ; Song, Changyou 1 ; Li, Hongxia 1 ;
作者机构： 1.Nanjing Agr Univ, Wuxi Fisheries Coll, Wuxi 214081, Jiangsu, Peoples R China
2.Chinese Acad Fishery Sci, Freshwater Fisheries Res Ctr, Key Lab Freshwater Fisheries & Germplasm Resources, Minist Agr & Rural Affairs, Wuxi 214081, Peoples R China
关键词： Aplodinotus grunniens; high-fat diet; starvation stress; lipid deposition; oxidative stress; PPAR signaling
期刊名称：ANTIOXIDANTS （ 影响因子：7.0； 五年影响因子：7.3 ）
ISSN：
年卷期： 2023 年 12 卷 8 期
页码：
收录情况： SCI
摘要： The appropriate level of dietary lipids is essential for the nutrient requirements, rapid growth, and health maintenance of aquatic animals, while excessive dietary lipid intake will lead to lipid deposition and affect fish health. However, the symptoms of excessive lipid deposition in the liver of freshwater drums (Aplodinotus grunniens) remain unclear. In this study, a 4-month rearing experiment feeding with high-fat diets and a 6-week starvation stress experiment were conducted to evaluate the physiological alteration and underlying mechanism associated with lipid deposition in the liver of A. grunniens. From the results, high-fat-diet-induced lipid deposition was associated with increased condition factor (CF), viscerosomatic index (VSI), and hepatosomatic index (HSI). Meanwhile, lipid deposition led to physiological and metabolic disorders, inhibited antioxidant capacity, and exacerbated the burden of lipid metabolism. Lipid deposition promoted fatty acid synthesis but suppressed catabolism. Specifically, the transcriptome and metabolome showed significant enrichment of lipid metabolism and antioxidant pathways. In addition, the interaction analysis suggested that peroxisome proliferator-activated receptor (PPAR)-mediated 13-S-hydroxyoctadecenoic acid (13 (s)-HODE) could serve as the key target in regulating lipid metabolism and oxidative stress during lipid deposition in A. grunniens. Inversely, with a lipid intake restriction experiment, PPARs were confirmed to regulate lipid expenditure and physiological homeostasis in A. grunniens. These results uncover the molecular basis of and provide specific molecular targets for fatty liver control and prevention, which are of great importance for the sustainable development of A. grunniens.
- 相关文献
作者其他论文 更多>>
-
Aquaculture in Zambia: The Current Status, Challenges, Opportunities and Adaptable Lessons Learnt from China
作者：Zhang, Lin;Hua, Fenglei;Xu, Pao;Zhang, Lin;Hua, Fenglei;Xu, Pao;Maulu, Sahya;Maulu, Sahya;Chama, Majory K. H.
关键词：Zambia; aquaculture; challenges; adaptable lessons
-
Integrated analysis of physiological, transcriptome, and metabolome analyses of the gills in Solenaia oleivora under ammonia exposure
作者：Zhang, Ting;Wen, Haibo;Xu, Dongpo;Zhang, Ting;Zhou, Yanfeng;Xu, Dongpo;Wen, Haibo;Ma, Xueyan
关键词：Mollusk; Ammonia; Transcriptome; Metabolome; Immune
-
Metagenomic Insight into the Effect of Probiotics on Nitrogen Cycle in the Coilia nasus Aquaculture Pond Water
作者：Mang, Qi;Xu, Gangchun;Xu, Pao;Mang, Qi;Gao, Jun;Li, Quanjie;Sun, Yi;Xu, Gangchun;Xu, Pao
关键词：probiotics; ammonia; nitrite; nitrogen cycling; nitrification; denitrification
-
Integrative analysis of miRNA-mRNA expression in the brain during high temperature-induced masculinization of female Nile tilapia ( Oreochromis niloticus )
作者：Jiang, Bingjie;Lu, Siqi;Dong, Yalun;Xu, Pao;Qiang, Jun;Tao, Yifan;Li, Yan;Xu, Pao;Qiang, Jun;Badran, M. F.;Qiang, Jun;Tao, Yifan
关键词：Oreochromis niloticus; Brain tissues; High temperature -induced; Sex reversal; miRNA-mRNA expression
-
Comparative analysis of gut microbiota and intestinal transcriptomic profile between fast- and slow-growing American eels (Anguilla rostrata)
作者：Zhang, Yu Ting;Huang, Jing;Chen, Shi Xi;Zhang, Yu Ting;Mu, Jingli;Jin, Wu;Ma, Xueyan;Lv, Guohua;Wen, Haibo;Jin, Wu;Wen, Haibo;Ye, Changlin
关键词：American eel; Growth; Gut microbiota; Transcriptome
-
A High-Fat-Diet-Induced Microbiota Imbalance Correlates with Oxidative Stress and the Inflammatory Response in the Gut of Freshwater Drum (Aplodinotus grunniens)
作者：Xue, Miaomiao;Xu, Pao;Wen, Haibo;Chen, Jianxiang;Wang, Qingyong;He, Jiyan;He, Changchang;Kong, Changxin;Li, Xiaowei;Li, Hongxia;Song, Changyou;Xu, Pao;Wen, Haibo;Chen, Jianxiang;Li, Hongxia;Song, Changyou
关键词：high-fat diet; gut microbiota; physiological homeostasis; Aplodinotus grunniens
-
Comparative transcriptomics and metabolomics reveal specific biochemical responses in cultured largemouth bass ( Micropterus salmoides ) juveniles with sexual dimorphism
作者：Li, Yan;Wang, Qingchun;Qiang, Jun;Xu, Pao;Li, Yan;Hua, Jixiang;Tao, Yifan;Lu, Siqi;Dong, Yalun;Jiang, Bingjie;Qiang, Jun;Xu, Pao
关键词：Largemouth bass; Sexual dependence; Lipid droplets; Differentially expressed genes; Differential metabolites
