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Metabolic response of Sinosolenaia oleivora to heat and drought stress using a quasi-targeted metabolomics approach

文献类型： 外文期刊

作者： Ma, Xueyan 1 ; Jin, Wu 1 ; Wang, Liufu 1 ; Chen, Wanwen 1 ; Wang, Yufeng 1 ; Wen, Haibo 1 ; Cao, Xiaojuan 3 ;

作者机构： 1.Chinese Acad Fishery Sci, Freshwater Fisheries Res Ctr, Key Lab Integrated Rice Fish Farming Ecol, Minist Agr & Rural Affairs, Wuxi 214081, Peoples R China

2.Chinese Acad Fishery Sci, Freshwater Fisheries Res Ctr, Sino US Cooperat Lab Germplasm Conservat & Utiliza, Wuxi 214081, Peoples R China

3.Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Peoples R China

关键词： Metabolic response; Metabolome; Heat stress; Drought stress; Freshwater mussel

期刊名称：COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS （ 影响因子：2.4； 五年影响因子：2.8 ）

ISSN： 1744-117X

年卷期： 2025 年 55 卷

页码：

收录情况： SCI

摘要： Global climate change has subjected freshwater organisms to environmental stressors, such as heat and drought; however, little remains known about their metabolic response to these stressors. Herein we performed quasi-targeted metabolomic analysis to investigate the metabolic response of Sinosolenaia oleivora gills under heat and drought stress. The survival rate of S. oleivora under 48-h heat stress did not significantly differ from that in the control group; however, in the drought group, the mortality rate was >50 % at 24 h, and complete mortality occurred within 48 h, with significantly lower survival rates than the conventional and heat groups. Overall, 747 metabolites were identified across the three groups. Orthogonal partial least squares discriminant and clustering heatmap analyses indicated that both heat and drought stress significantly impacted the gill metabolome of S. oleivora. In the heat group (sc), compared to the conventional group (s), 17 metabolites were significantly upregulated and 46 were significantly downregulated. Eight metabolic pathways were significantly affected: pyruvate metabolism, propanoate metabolism, adrenergic signaling in cardiomyocytes, tyrosine metabolism, butanoate metabolism, nicotinate and nicotinamide metabolism, citrate cycle (tricarboxylic acid cycle), and oxidative phosphorylation. In the drought group (sd), compared to the heat group (sc), 26 metabolites were significantly upregulated and four were significantly downregulated. Three metabolic pathways showed significant differences: longevity regulating pathway-worm, GABAergic synapse, estrogen signaling pathway. We believe that succinic acid and fumaric acid can serve as indicators of heat stress, while nicotinamide and 4-aminobutyric acid can serve as biomarkers of drought stress in S. oleivora.

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