您好，欢迎访问中国水产科学研究院 机构知识库！
中国水产科学研究院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Genomic selection for resistance to Streptococcus agalactiae in GIFT strain of Oreochromis niloticus by GBLUP, wGBLUP, and BayesC pi

文献类型： 外文期刊

作者： Lu, Sheng 1 ; Zhu, Jiajie 3 ; Du, Xiao 4 ; Sun, Shuai 4 ; Meng, Liang 1 ; Liu, Shanshan 4 ; Fan, Guangyi 4 ; Wang, Jie 1 ; C 1 ;

作者机构： 1.Chinese Acad Fisheries Sci, Yellow Sea Fisheries Res Inst, Qingdao 266071, Peoples R China

2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266071, Peoples R China

3.Guangxi Acad Fishery Sci, Guangxi Key Lab Aquat Genet Breeding & Hlth Aquac, Nanning 530021, Guangxi, Peoples R China

4.BGI Shenzhen, BGI Qingdao, Qingdao 266071, Peoples R China

5.Nanjing Agr Univ, Wuxi Fisheries Coll, Wuxi, Jiangsu, Peoples R China

关键词： Genomic selection; Streptococcus agalactiae; Disease resistance; Oreochromis niloticus

期刊名称：AQUACULTURE （ 影响因子：4.242； 五年影响因子：4.723 ）

ISSN： 0044-8486

年卷期： 2020 年 523 卷

页码：

收录情况： SCI

摘要： China is the largest producer of tilapia in the world, and genetically improved farmed tilapia (GIFT) strain of Oreochromis niloticus is the main breed which is cultured widely in coastal and inland areas of China. Streptococcal disease, caused by Streptococcus agalactiae, is one of the most prevalent diseases in farmed tilapia that causes huge economic loss, leading to urgent needs for disease-resistant breed of tilapia. In view of the predictive accuracy and selective efficiency, genomic selection (GS) could be a feasible and optimal method to improve the S. agalactiae resistance in GITF. In this study, the genetic architecture of resistance to S. agalactiae and the accuracy of three GS methods at improving the resistance in GIFT were investigated by artificial challenge test (for phenotypes) and whole-genome re-sequencing (for genotypes). A total of 897 individuals were genotyped (776 individuals were used as the reference group) and 3,759,557 high-quality SNPs were obtained for downstream analysis. The genome-wide association study (GWAS) using weighted genomic BLUP (wGBLUP) and 1 M SNPs revealed that resistance to S. agalactiae in GIFT belongs to a polygenic genetic architecture. Seven suggestive trait-related SNPs were identified on chromosomes 4, 7, 11, and 18. These SNPs explained more than 1% genetic variance. Three GS (GBLUP, wGBLUP, and BayesC pi) methods had better estimation than pedigree-based BLUP, which indicated that the genomic selection approach could be a feasible and promising method to improve the S. agalactiae resistance in GIFT. Although wGBLUP and BayesC pi resulted in similar estimation accuracy, wGBLUP had priority when estimating time needs to be considered.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：中国水产科学研究院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台