文献类型： 外文期刊
作者： Qian, Le 1 ; Liu, Jia 1 ; Lin, Zhipeng 3 ; Chen, Xiaofeng 2 ; Yuan, Lilai 1 ; Shen, Gongming 1 ; Yang, Wenbo 1 ; Wang, Do 1 ;
作者机构： 1.Chinese Acad Fishery Sci, Fishery Resource & Environm Res Ctr, Beijing, Peoples R China
2.China Agr Univ, Coll Sci, Beijing, Peoples R China
3.Nanjing Agr Univ, Coll Resources & Environm Sci, Nanjing, Peoples R China
4.Peking Univ, Coll Life Sci, Beijing, Peoples R China
关键词： Phthalates; Zebrafish embryo; Spinal effects; Behavioral effect
期刊名称：CHEMOSPHERE （ 影响因子：7.086； 五年影响因子：6.956 ）
ISSN： 0045-6535
年卷期： 2020 年 249 卷
页码：
收录情况： SCI
摘要： Phthalates (phthalate esters, PAEs) are commonly used as plasticizers and are emerging concerns worldwide for their potential influence on the environment and general public health. Thus, identification of the negative effects and involved mechanisms of PAEs is necessary. Herein, we found that embryonic exposure of zebrafish to di-(2-ethylhexyl) phthalate (DEHP) and di-butyl phthalate (DBP) significantly induced spinal defects, such as inhibited spontaneous movement at 24 h post-fertilization (hpf), spine curvature and body length decrease at 96 hpf. The transcriptional level of the genes that are related to the development of the notochord (col8a1a and ngs), muscle (stac3, klhl41a and smyd2b) and skeleton (bmp2, spp1) were significantly altered by DEHP and DBP at 50 and 250 mu g/L, which might be associated with the observed morphological changes. Notably, DBP and DEHP altered the locomotor activity of zebrafish larvae at 144 hpf, which might be due to the abnormal development of the spine and skeletal system. In conclusion, phthalates caused spinal birth defects in zebrafish embryos, induced transcriptional alterations of the spinal developmental genes, and led to abnormal behavior. (C) 2020 Elsevier Ltd. All rights reserved.
- 相关文献
作者其他论文 更多>>
-
Application of microalgae in remediation of heavy metal-contaminated soils and its stimulatory effect on wheat growth
作者：Liu, Jia;Liu, Yajing;Jiang, Han;Yang, Xiaokun;Wu, Yukun;Liang, Chengwei;Zhang, Xiaowen;Ye, Naihao;Zhang, Xiaowen;Ye, Naihao
关键词：Microalgae; Heavy metal-contaminated soils; Bioremediation; Soil fertility; Wheat growth
-
Dual impacts of elevated pCO2 on the ecological effects induced by microplastics and nanoplastics: A study with Chlamydomonas reinhardtii
作者：Liang, Chengwei;Liu, Yajing;Xi, Tianle;Liu, Jia;Jia, Zhihua;Liang, Chengwei;Ge, Shanshan;Zhang, Xiaowen;Ye, Naihao;Zhang, Xiaowen;Ye, Naihao
关键词：Micro-and nanoplastics; and nanoplastics; Freshwater acidification; Combined toxicity; Mechanisms; Oxidative stress; Chlamydomonas reinhardtii
-
Tailoring a donor-acceptor structure in oxygen and cyano group co-modified carbon nitride for enhanced photocatalytic imidacloprid degradation
作者：Li, Ling;Zeng, Hao;Zhong, Liqiao;Zheng, Jin;Zhou, Zhanpeng;Liu, Jiawei;Deng, Yaocheng;Huang, Ying;Li, Ling;Zeng, Hao;Zhou, Zhanpeng;Tang, Rongdi;Huang, Ying;Zhong, Liqiao;Wu, Hao
关键词：Carbon nitride; Photocatalysis; Donor-accepter; Imidacloprid degradation
-
Comparative disinfection efficacy in aquaculture: novel methylene bis(thiocyanate) vs. conventional trichloroisocyanuric acid against Aeromonas hydrophila
作者：Yang, Guang;Zhang, Lian-bo;Huang, Ying;Ma, Ning;Li, Kai;Wang, Xiao-mei;Yang, Wen-bo;Zhang, Wan-li;Zhang, Hong-Yu;Yuan, Li-lai;Huang, Ying;Ma, Ning;Li, Kai;Wang, Xiao-mei;Yang, Wen-bo;Zhang, Wan-li;Xia, Lei;Zhang, Hong-Yu;Yuan, Li-lai
关键词：
Aeromonas ; methylene bis (thiocyanate); trichloroisocyanuric acid; disinfection; aquaculture -
Transcriptome analysis reveals the DNA replication genes response to Vibrio anguillarum and NNV infection in Jinhu grouper (Epinephelus fuscoguttatus♀ x Epinephelus tukulal♂)
作者：Duan, Huimin;Li, Zhentong;Tian, Yongsheng;Duan, Huimin;Zhang, Yazhuo;Liu, Jia;Ren, Gehui
关键词：Vibrio anguillarum; Neuronal necrosis virus; DNA replication; Grouper; RNA-Seq
-
Sub-Chronic Methomyl Exposure Induces Oxidative Stress and Inflammatory Responses in Zebrafish with Higher Female Susceptibility
作者：Li, Mingxiao;Chen, Xi;Song, Chao;Fan, Limin;Meng, Shunlong;Chen, Xi;Song, Chao;Fan, Limin;Qiu, Liping;Li, Dandan;Xu, Huimin;Meng, Shunlong;Xu, Jing;Mu, Xiyan;Xia, Bin;Ling, Jun
关键词：methomyl; oxidative stress; inflammation; sex differences; zebrafish
-
Effects of phoxim on antibacterial infection of silver carp
作者：Yang, Yibin;Ma, Ning;Huang, Ying;Yang, Wenbo;Liu, Tao;Zhang, Hongyu;Yang, Yibin;Zhu, Xia
关键词：Hypophthalmichthys molitrix; Phoxim; Aeromonas veronii; Sepsis; Gut microbe
