文献类型： 外文期刊
作者： Li, Ming 1 ; Yao, Liang 1 ; Chen, Hao 1 ; Ni, Xuan 1 ; Xu, Yao 1 ; Dong, Wengjing 1 ; Fang, Mingliang 4 ; Chen, Da 5 ; Aowul 1 ;
作者机构： 1.Inner Mongolia Univ Nationalities, Inner Mongolia Key Lab Toxicant Monitoring & Toxi, Coll Anim Sci & Technol, Tongliao 028000, Inner Mongolia, Peoples R China
2.Shanghai Ocean Univ, Natl Demonstrat Ctr Expt Fisheries Sci Educ, Shanghai 201306, Peoples R China
3.Chinese Acad Fishery Sci, Funct Lab Marine Fisheries Sci & Food Prod Proc,Y, Yellow Sea Fisheries Res Inst,Minist Agr,Qingdao, Qingdao Natl Lab Marine Sci & Technol,Key Lab Mar, Qingdao 266071, Peoples R China
4.Nanyang Technol Univ, Sch Civil & Environm Engn, 50 Nanyang Ave, Singapore 639798, Singapore
5.Jinan Univ, Sch Environm, Guangdong Key Lab Environm Pollut & Hlth, Guangzhou 510632, Guangdong, Peoples R China
6.Inner Mongolia Univ Nationalities, Coll Tradit Mongolian Med & Pharm, Tongliao 028000, Inner Mongolia, Peoples R China
7.Inner Mongolia Univ Nationalities, Coll Chem & Chem Engn, Tongliao 028000, Inner Mongolia, Peoples R China
8.Acad Mil Med Sci, Acad Mil Med Sci, Inst Toxicol & Pharmacol, State Key Lab Toxicol & Med Countermeasures, Beijing 100850, Peoples R China
9.Zunyi Med Univ, Key Lab Basic Pharmacol, Minist Educ, Zunyi 563000, Guizhou, Peoples R China
10.Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Y823, Hong Kong, Peoples R China
关键词： Muscone; Zebrafish embryo; Cardiotoxicity; Atrial/Ventricular myosin heavy Chain; Chirality
期刊名称：AQUATIC TOXICOLOGY （ 影响因子：4.964； 五年影响因子：5.071 ）
ISSN： 0166-445X
年卷期： 2020 年 222 卷
页码：
收录情况： SCI
摘要： Musk compounds are often used as to treat heart-related diseases and are widely used in Asia. Muscone is one of the most important physiologically active compounds of natural musk. Muscone is a chiral compound and can be further classified into S-muscone and R-muscone and both are present in synthetic musk. While these two chiral isomers have significant differences in odor properties, their difference in toxicity is still unknown. This study used zebrafish as an animal model to compare cardiac toxicities of S-muscone and R-muscone. Results showed that both compounds were acutely toxic to zebrafish embryos causing mortality, decreased hatching rate, pericardial edema, and decreased heart beat rate. These toxicities were modulated through increased Myh6 and Myh7 mRNA expression, and decreased thyroid genes (Trh, Thr beta, and Dio3) expression. R-muscone caused higher toxicity than S-muscone at the same concentration. For safety, the chiral isomer composition of synthetic muscone should be carefully regulated in the future.
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