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Metabolomics-guided analysis reveals a two-step epimerization of deoxynivalenol catalyzed by the bacterial consortium IFSN-C1

文献类型： 外文期刊

作者： Wang, Gang 1 ; Wang, Yanxia 1 ; Man, Huizi 3 ; Lee, Yin-Won 4 ; Shi, Jianrong 1 ; Xu, Jianhong 1 ;

作者机构： 1.Jiangsu Acad Agr Sci, Inst Food Safety & Nutr,State Key Lab Cultivat Ba, Minist Sci & Technol,Minist Agr & Rural Affairs,K, Jiangsu Key Lab Food Qual & Safety,Collaborat Inn, Nanjing, Peoples R China

2.Jiangsu Univ, Sch Food & Biol Engn, Zhenjiang, Peoples R China

3.Shandong Agr Univ, Coll Life Sci, Dept Microbiol, Key Lab Agr Microbiol, Tai An, Peoples R China

4.Seoul Natl Univ, Sch Agr Biotechnol, Seoul 08826, South Korea

关键词： Deoxynivalenol; Biodegradation; Fusarium mycotoxins; Metabolomics

期刊名称：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY （ 影响因子：4.813； 五年影响因子：4.697 ）

ISSN： 0175-7598

年卷期： 2020 年 104 卷 13 期

页码：

收录情况： SCI

摘要： Deoxynivalenol (DON) is commonly found in wheat and wheat-derived foods, posing a threat to human health. Biodegradation is an efficient and eco-friendly measure for mycotoxin detoxification. Understanding the mechanism of DON biodegradation is hence of great importance. Herein, we report the application of metabolomics methods for the analysis of DON degradation by a bacterial consortium isolated from wheat leaves collected in Jiangsu Province. Metabolomics analysis combined with a nuclear magnetic resonance analysis revealed the main degradation product, 3-keto-DON, and a minor degradation product, 3-epi-DON. Further study illustrated that DON underwent a two-step epimerization through the intermediate 3-keto-DON. Sequencing analysis of the 16S rRNA metagenome of the microorganismal community suggested that the abundance of three bacterial genera, Achromobacter, Sphingopyxis, and Sphingomonas, substantially increased during the coculture of bacterial consortium and DON. Further investigation revealed that Devosia sp. might be responsible for the epimerization of 3-keto-DON. These findings shed light on the catabolic pathways of DON during biodegradation and illustrate the potential of using metabolomics approaches in biodegradation studies.

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