Genetic effect and combined genotype effect of ESR, FSH beta, CTNNAL1 and miR-27a loci on litter size in a Large White population
文献类型： 外文期刊
作者： Pang, Panfei 1 ; Li, Zhenzhu 1 ; Hu, Hua 3 ; Wang, Lei 1 ; Sun, Hua 3 ; Mei, Shuqi 3 ; Li, Fenge 1 ;
作者机构： 1.Huazhong Agr Univ, Key Lab Pig Genet & Breeding, Minist Agr, Wuhan 430070, Peoples R China
2.Huazhong Agr Univ, Key Lab Agr Anim Genet Breeding & Reprod, Minist Educ, Wuhan 430070, Peoples R China
3.Hubei Acad Agr Sci, Hubei Key Lab Anim Embryo Engn & Mol Breeding, Wuhan, Peoples R China
4.Cooperat Innovat Ctr Sustainable Pig Prod, Wuhan, Peoples R China
关键词： Pig; litter size; genetic marker; MBLUP
期刊名称：ANIMAL BIOTECHNOLOGY （ 影响因子：2.282； 五年影响因子：1.702 ）
ISSN： 1049-5398
年卷期： 2019 年 30 卷 4 期
页码：
收录情况： SCI
摘要： To select new Large White line with high number of piglets born, genotypes of estrogen receptor (ESR), the follicle stimulating hormone b subunit (FSHb), catenin alpha like 1 (CTNNAL1) and miR-27a were tested in 472 Large White sows. The associations of different genotypes with litter size traits were also studied. The results showed ESRBB and FSH beta(BB) sows produced 0.41-1.49 more pigs per litter (p<.05) for total number born (TNB) and number born alive (NBA) than did other corresponding genotypes. TNB of CTNNAL1(CG) sows is 0.50 more pigs per litter (p<.05) than that of CTNNAL1(GG) sows with the dominance effect of 0.25 pigs per litter (p<.05). miR-27aBB sows had a less estimated breeding value (EBV) to TNB and had a more number of mummified pigs (NM) than did miR-27aAA or miR27aAB sows (p<.05). Therefore, ESRB, FSH beta(B), CTNNAL1(G), miR-27a(A) allele was favorable for litter size traits. Furthermore, combined genetic effect analysis showed ESRAAFSH beta(BB), ESRAACTNNAL1(CG), ESR(AA)miR-27a(AA), FSH beta(BB)CTNNAL1(CC), FSH beta(BB)miR-27a(AA) and CTNNAL1(CG) miR-27a(AB) was the favorable combined genotype for litter size traits. These results identified favorable alleles and genotypes for litter size traits and suggested a potential selection scheme for litter size in Large White pigs.
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