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Sulfur-containing natural hinduchelins derivatives as potential antifungal agents against Rhizoctonia solani

文献类型： 外文期刊

作者： Ke, Shaoyong 1 ; Fang, Wei 1 ; Huang, Wenbo 1 ; Zhang, Zhigang 1 ; Shi, Liqiao 1 ; Wan, Zhongyi 1 ; Wang, Kaimei 1 ; Cao, 1 ;

作者机构： 1.Hubei Acad Agr Sci, Natl Biopesticide Engn Res Ctr, Hubei Biopesticide Engn Res Ctr, Wuhan 430064, Peoples R China

关键词： Hinduchelins derivatives; Sulfur-containing derivatives; Natural products; Antifungal activity

期刊名称：BIOORGANIC & MEDICINAL CHEMISTRY LETTERS （ 影响因子：2.823； 五年影响因子：2.677 ）

ISSN： 0960-894X

年卷期： 2020 年 30 卷 13 期

页码：

收录情况： SCI

摘要： Aryl-oxazole alkaloids are an important class of heterocyclic natural products, and which has been demonstrated to exhibit broad biological functions. During the course of our research for highly active compounds from natural products, the natural hinduchelins A-D with typical aryl-oxazole unit have been synthesized and investigated. So, in order to develop highly potential functional molecules, a series of novel sulfur-containing aryl-oxazole compounds derived from natural hinduchelins was designed and synthesized, and their in vitro fungicidal activities against four common plant pathogenic fungi (oomycetes Phytophthora capsici, ascomycetes Sclerotinia sclerotionim, deuteromycetes Botrytis cinerea and basidiomycetes Rhizoctonia solani) were evaluated, the results demonstrated that compounds 7b and 7c displayed good selectivity and specificity in vitro against basidiomycetes R. solani. In addition, the in vivo antifungal activities also indicated compounds 7b and 7c can protect the horsebean against infection by R. solani, and the possible mechanism of antifungal action for these compounds has also been investigated.

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