文献类型： 外文期刊

作者： Li, Q. Q. ¹ ; Wan, K. X. ¹ ; Xu, M. S. ² ; Wang, L. M. ² ; Zhang, Y. Y. ² ; Wang, C. T. ¹ ; Mao, F. X. ¹ ; Zhu, J. L. ¹ ; Pa ¹ ;

作者机构： 1.Shihezi Univ, Sch Med, Dept Basic Med Sci, Shihezi 832000, Peoples R China

2.Xinjiang Acad Agr & Reclamat Sci, State Key Lab Sheep Genet Improvement & Hlth Prod, Shihezi 832000, Peoples R China

关键词： TASK-1; respiratory center; central chemoreceptors; AEA; respiratory regulation

期刊名称：MOLECULAR BIOLOGY （ 影响因子：1.374； 五年影响因子：1.266 ）

ISSN： 0026-8933

年卷期： 2020 年 54 卷 3 期

页码：

收录情况： SCI

摘要： TWIK-related acid-sensitive potassium channel-1 (TASK-1) is a "leak" potassium channel sensitive to extracellular protons. It contributes to setting the resting potential in mammalian neurons. TASK-1 channels are widely expressed in respiratory-related neurons in the central nervous system. Inhibition of TASK-1 by extracellular acidosis can depolarize and increase the excitability of these cells. Here we describe the distribution of TASK-1 in the rat brainstem and show that TASK-1 mRNAs are present in respiratory-related nuclei in the ventrolateral medulla, which have been proposed as neural substrates for central chemoreception in rats. After inhalation of 8% CO(2)for 30 and 60 min, TASK-1 mRNA levels in positive-expression neurons were remarkably upregulated. Injection of the TASK-1 blocker anandamide (AEA) into the rat lateral cerebral ventricle, showed a significant excitement of respiratory at 10 min posttreatment, with a marked decrease in inspiratory and expiratory durations and an increased frequency of respiration. We suggest that TASK-1 channel may serve as a chemosensor for in central respiration and may contribute to pH-sensitive respiratory effects. TASK-1 channel might be an attractive candidate for sensing H+/CO(2)in several respiratory-related nuclei in the brainstem. It is likely that TASK-1 participates in pH-sensitive chemical regulation in the respiratory center under physiological and pathological conditions.