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Chiral drug fluorometry based on a calix[6]arene/molecularly imprinted polymer double recognition element grafted on nano-C-dots/Ir/Au

文献类型： 外文期刊

作者： Li, Shuhuai 1 ; Pang, Chaohai 1 ; Ma, Xionghui 1 ; Zhao, Min 1 ; Li, Haibo 1 ; Wang, Mingyue 1 ; Li, Jianping 2 ; Luo, Ji 1 ;

作者机构： 1.Chinese Acad Trop Agr Sci, Hainan Prov Key Lab Qual & Safety Trop Fruits & V, Anal & Test Ctr, Haikou 571101, Hainan, Peoples R China

2.Guilin Univ Technol, Coll Chem & Bioengn, Guilin 541004, Peoples R China

关键词： Nanoprobe; Molecularly imprinted polymer; Calix[6]arene; Chiral drug

期刊名称：MICROCHIMICA ACTA （ 影响因子：5.833； 五年影响因子：5.357 ）

ISSN： 0026-3672

年卷期： 2020 年 187 卷 7 期

页码：

收录情况： SCI

摘要： A luminescent double recognition nanoprobe is described as a new strategy for the selective determination of chiral molecules. C-dots/Ir/Au fluorescent nanoparticles, synthesised under hydrothermal conditions, are used as a high-performance probe in combination with a molecularly imprinted polymer (MIP) and calix[6]arene as a double recognition element. Thiolated calix[6]arene is grafted on C-dots/Ir/Au as the first recognition element, which then forms a host-guest complex with the target molecule levodopa (L-DOPA). Subsequently, an MIP is prepared on the C-dots/Ir/Au (MIP/C-dots/Ir/Au) by chemical polymerisation. After the removal of L-DOPA, double recognition imprinting cavities are formed. The fluorescence intensity at 478 nm of the nanoprobe is effectively quenched by adsorption of L-DOPA on MIP/C-dots/Ir/Au, which provides a method for L-DOPA determination. Owing to the double recognition strategy, this method has excellent selectivity which can effectively avoid interference from enantiomer D-DOPA, and a imprinting factor of 7.1 is obtained for L-DOPA. This accurate and reliable method, with a wide linear range (5 x 10(-10)to 1.2 x 10(-7) mol L-1) and a low limit of detection (1.45 x 10(-10) mol L-1), was successfully applied to the determination of L-DOPA in real samples, giving standard recoveries of 89.7-110.0%. Thus, the proposed sensing method provides a viable approach for the determination of a single enantiomer. Schematic presentation of the MIP/C-dots/Ir/Au for L-DOPA detection. A fluorescence double chiral recognition nanoprobe is prepared of C-dots/Ir/Au nanoparticles as signal probe, and a molecularly imprinted polymer (MIP) and calix[6]arene as a double recognition element. Owing to the double recognition strategy, this method has strong specificity and can effectively avoid interference from enantiomers and racemates.

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