Design, synthesis and bioactivity evaluation of novel thioether derivatives containing a sulfonohydrazide moiety
文献类型： 外文期刊
作者： Li, Pei 1 ; Zhou, Junliang 2 ; Liu, Yan 3 ; Wang, Xiang 1 ;
作者机构： 1.Kaili Univ, Qiandongnan Engn & Technol Res Ctr Comprehens Uti, Key Lab Modernizat Qiandongnan Miao & Dong Med, Kaili, Peoples R China
2.Guizhou Acad Agr Sci, Guizhou Fruit Inst, Guiyang, Peoples R China
3.Natl Chem Low Carbon Technol & Engn Ctr, Kunshan, Peoples R China
关键词： Synthesis; antibacterial activity; thioether; sulfonohydrazide
期刊名称：PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS （ 影响因子：1.082； 五年影响因子：0.859 ）
ISSN： 1042-6507
年卷期： 2020 年 195 卷 12 期
页码：
收录情况： SCI
摘要： A series of novel thioether derivatives containing a sulfonohydrazide moiety were synthesized and determined using(1)H NMR,C-13 NMR, HRMS, and elemental analysis. Theirin vitroantibacterial activities againstXanthomonas oryzaepv.oryzae(Xoo) andXanthomonas axonopodispv.citri(Xac) were investigated by performing turbidimeter test. Bioassay results showed that some of the target compounds revealed moderate to good antibacterial activities againstXooandXac. Especially,N'-(2-(ethylthio)acetyl)-4-fluorobenzenesulfonohydrazide (4p) revealed the best bioactivities againstXooandXac, with the 50% effective concentration (EC50) values of 13.75 and 18.56 mu g/mL, respectively, which were even better than those of thiodiazole copper and bismerthiazol.
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