文献类型： 外文期刊
作者： Feng, Min 1 ; Kolliopoulou, Anna 2 ; Zhou, Yao-Hong 1 ; Fei, Shi-Gang 1 ; Xia, Jun-Ming 1 ; Swevers, Luc 2 ; Sun, Jing 1 ;
作者机构： 1.South China Agr Univ, Coll Anim Sci, Guangdong Prov Key Lab Agro Anim Genom & Mol Bree, 483 Wushan Rd, Guangzhou 510642, Peoples R China
2.Natl Ctr Sci Res Demokritos, Inst Biosci & Applicat, Insect Mol Genet & Biotechnol, P Grigoriou & Neapoleos St, Athens 15310, Greece
关键词： BmNPV; fat body; midgut; piRNA; silkworm
期刊名称：INSECT SCIENCE （ 影响因子：3.262； 五年影响因子：3.206 ）
ISSN： 1672-9609
年卷期：
页码：
收录情况： SCI
摘要： Bombyx morinucleopolyhedrovirus (BmNPV) is a DNA virus that causes huge losses to the silkworm industry but the piRNA responses during BmNPV infection in the silkworm remain uninvestigated. Here, silkworm piRNA profiles of uninfected and BmNPV-infected fat body and midgut were determined by high-through sequencing in the early stages of BmNPV infection. A total of 2675 and 3396 genome-derived piRNAs were identified from fat body and midgut, respectively. These genome-derived piRNAs mainly originated from unannotated instead of transposon regions in the silkworm genome. In total, 572 piRNAs were associated with 280 putative target genes in fat body and 805 piRNAs with 380 target genes in midgut. Compared to uninfected tissues, 322 and 129 piRNAs were significantly upregulated in BmNPV-infected fat body and midgut, respectively. In addition, 276 and 117 piRNAs were significantly downregulated. Moreover, differentially expressed (DE) piRNAs during BmNPV infection differed significantly between fat body and midgut. Putative DE piRNA-targeted genes were associated with "response to stimulus" and "environmental information processing" in fat body after infection with BmNPV, which may indicate an active piRNA response to BmNPV infection in fat body. This study may lay the foundation for future research of the potential roles of the piRNA pathway and specific piRNAs in BmNPV pathogenesis.
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