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LC-Q-TOF-MS Characterization of Polyphenols from White Bayberry Fruit and Its Antidiabetic Effect in KK-A(y) Mice

文献类型： 外文期刊

作者： Liu, Yilong 1 ; Zhang, Xianan 2 ; Zhan, Liuhuan 1 ; Xu, Chang 1 ; Sun, Linxiao 3 ; Jiang, Huamin 4 ; Sun, Chongde 1 ; Li, 1 ;

作者机构： 1.Zhejiang Univ, Zhejiang Prov Key Lab Hort Plant Integrat Biol St, State Agr Minist, Lab Hort Plant Growth Dev & Qual Improvement, Hangzhou 310058, Peoples R China

2.Shanghai Acad Agr Sci, Forestry & Fruit Res Inst, Shanghai 201403, Peoples R China

3.Wenzhou Med Univ, Key Lab Diag & Treatment Severe Hepatopancreat Di, Zhejiang Prov Top Key Discipline Surg, Affiliated Hosp 1, Wenzhou 325000, Peoples R China

4.Hangzhou Lichuan Ecol Agr Dev Co Ltd, Hangzhou 311123, Peoples R China

期刊名称：ACS OMEGA （ 影响因子：3.512； 五年影响因子：3.613 ）

ISSN： 2470-1343

年卷期： 2020 年 5 卷 28 期

页码：

收录情况： SCI

摘要： The present study is to investigate the polyphenolic composition and in vivo antidiabetic effect of white-fleshed Chinese bayberry cultivar "Shui Jing". By liquid chromatography quadrupole time-of-flight mass spectrometry (LC-TOF- MS), 38 polyphenols were identified in the Shui Jing fruit extract (SJE), where proanthocyanidins (PAs), including epigallocatechin gallate (EGCG), as well as flavonols, including myricitrin and quercetrin, were the predominant ingredients. After a 5-week experiment, the SJE (200 mg/kg bodyweight) significantly reduced fasting blood glucose, elevated glucose tolerance, and insulin sensitivity in diabetic KK-A(y) mice. It markedly attenuated bodyweight gain and decreased glycolipid metabolism-related markers including insulin, leptin, glucagon, triglyceride (TG), total cholesterol (TC), lowdensity lipoprotein cholesterol (LDL-c) and alanine aminotransferase (ALT) levels in mice. Liver weight and hepatic lipid accumulation were also significantly reduced by the SJE. Gene expressions of insulin 1 (INS1) and glycogen synthase kinase 3 beta (GSK3b) were markedly inhibited while the hepatic phosphorylation of AMPK alpha was significantly increased in the liver of SJE-treated mice, indicating that the SJE may exert an antidiabetic effect through an AMPK-dependent pathway. In conclusion, white bayberry rich in PAs and flavonols may have great potential in the regulation of diabetes mellitus.

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