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Resveratrol promotes mammary cell proliferation and antioxidation capacity during pregnancy and lactation in mice

文献类型： 外文期刊

作者： Zha, C. 1 ; Xiao, H. 1 ; Song, B. 2 ; Zheng, C. 2 ; Yang, X. 1 ; Wang, W. 2 ; Wang, L. 1 ;

作者机构： 1.Guangdong Acad Agr Sci, State Key Lab Livestock & Poultry Breeding, Key Lab Anim Nutr & Feed Sci South China, Minist Agr,Maoming Branch,Guangdong Publ Lab Anim, Guangzhou, Peoples R China

2.South China Agr Univ, Coll Anim Sci, Guangdong Prov Key Lab Anim Nutr & Regulat, Guangzhou, Peoples R China

关键词： antioxidant; intestinal microbiota; mitophagy; reproduction; resveratrol

期刊名称：JOURNAL OF APPLIED MICROBIOLOGY （ 影响因子：3.772； 五年影响因子：3.963 ）

ISSN： 1364-5072

年卷期：

页码：

收录情况： SCI

摘要： Aims Reproduction can induce maternal oxidative stress, and resveratrol is able to alleviate oxidative stress. This study aimed to investigate the protective effects of resveratrol supplementation in mice during pregnancy and lactation. Methods and Results Pregnant mice were randomly divided into three groups: (i) Pure water (Con); (ii) Cellulose sodium dissolves with 20 mg kg(-1)resveratrol (R1) and (iii) Cellulose sodium dissolves with 40 mg kg(-1)resveratrol (R2). The experiment starts at pregnancy and ends at weaning. The results showed that resveratrol increased mammary cell proliferation and the mRNA expressions of UDP glucuronosyltransferase family 1 member A1 (UGT1A1) and cytochrome P450 proteins (CYP1A1), while decreased superoxide dismutase, extracellular (SOD3) in the mammary gland. Further study showed that resveratrol promoted the mRNA expressions of genes involved in mitophagy, such as transcription factor E beta (Tfe beta), Bcl1lc3 beta, homosapiens microtubule-associated protein 1 light-chain 3 beta (Map1lc3 beta), Parkin, sequestosome1 (p62), autophagy-related protein (Atg5) and Beclin-1 (Becn1) in the mammary gland. Moreover, resveratrol increased the abundances of some intestinal microbial species. 40 mg kg(-1)resveratrol significantly increased the contents ofAcidobacteri,unidentified acidbacteria,Bacilales, Staphylococcaceae andStaphylococcusat phylum, class, order, family and genus level respectively. Conclusion Our results indicate that resveratrol supplementation may promote mammary cell proliferation and antioxidant ability through mitophagy and regulating gut microbiota in pregnant mice. Significance and Impact of the Study Current study proved that resveratrol could affect mammary cell proliferation and antioxidation capacity during pregnancy and lactation in mice for the first time. The underlying mechanisms may be related to mitophagy and gut microbiota.

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