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Oral Administration of Bovine and Porcine Milk Exosome Alter miRNAs Profiles in Piglet Serum

文献类型： 外文期刊

作者： Lin, Delin 1 ; Chen, Ting 1 ; Xie, Meiying 1 ; Li, Meng 1 ; Zeng, Bin 1 ; Sun, Ruiping 2 ; Zhu, Yanling 1 ; Ye, Dingze 1 ; W 1 ;

作者机构： 1.South China Agr Univ, Natl Engn Res Ctr Breeding Swine Ind,Guangdong Pr, Guangdong Prov Res Ctr Woody Forage Engn & Techno, Guangdong Prov Key Lab Agroanim Genom & Mol Breed, 483 Wushan Rd, Guangzhou 510642, Peoples R China

2.Hainan Acad Agr Sci, Inst Anim Sci & Vet Med, Haikou 571100, Hainan, Peoples R China

期刊名称：SCIENTIFIC REPORTS （ 影响因子：4.379； 五年影响因子：5.133 ）

ISSN： 2045-2322

年卷期： 2020 年 10 卷 1 期

页码：

收录情况： SCI

摘要： Breast milk is the most important nutrient source for newborn mammals. Studies have reported that milk contains microRNAs (miRNAs), which are potential regulatory components. Currently, existing functional and nutritional two competing hypotheses in milk field though little date have been provided for nutritional hypothesis. In this study, we used the qRT-PCR method to evaluated whether milk miRNAs can be absorbed by newborn piglets by feeding them porcine or bovine milk. The result showed that miRNA levels (miR-2284x, 2291, 7134, 1343, 500, 223) were significantly different between bovine and porcine milk. Four miRNAs (miR-2284x, 2291, 7134, 1343) were significantly different in piglet serum after feeding porcine or bovine milk. After separated milk exosomes by ultracentrifugation, the results showed the selected milk miRNAs (miR-2284x, 2291, 7134, 1343) were present in both exosomes and supernatants, and the miRNAs showed the coincidental expression in IPEC-J2 cells. All our founding suggested that the milk miRNAs can be absorbed both in vivo and in vitro, which will building the foundation for understanding whether these sort of miRNAs exert physiological functions after being absorbed and provided additional evidence for the nutritional hypotheses.

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