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Polysaccharide from Gracilaria Lemaneiformis prevents colitis in Balb/c mice via enhancing intestinal barrier function and attenuating intestinal inflammation

文献类型： 外文期刊

作者： Han, Rui 1 ; Wang, Li 2 ; Zhao, Zhengang 1 ; You, Lijun 1 ; Pedisic, Sandra 4 ; Kulikouskaya, Viktoryia 5 ; Lin, Zhiqi 6 ;

作者机构： 1.South China Univ Technol, Sch Food Sci & Engn, 381 Wushan Rd, Guangzhou 510640, Guangdong, Peoples R China

2.Guangdong Acad Agr Sci, Inst Anim Sci, Key Lab Anim Nutr & Feed Sci South China, Minist Agr, Guangzhou 510640, Guangdong, Peoples R China

3.Overseas Expertise Intro Ctr Food Nutr & Human Hl, Ctr 111, Guangzhou 510640, Guangdong, Peoples R China

4.Univ Zagreb, Fac Food Technol & Biotechnol, Prolaz Kasandrica 6, Zadar 23000, Croatia

5.Natl Acad Sci Belarus, Inst Chem New Mat, 36F Skaryna Str, Minsk 220141, BELARUS

6.Univ Birmingham, Sch Math, Birmingham B15 2TT, W Midlands, England

关键词： Sulfated polysaccharide; Gracilaria Lemaneiformis; Colitis; Tight junction proteins; Intestinal barrier

期刊名称：FOOD HYDROCOLLOIDS （ 影响因子：9.147； 五年影响因子：9.169 ）

ISSN： 0268-005X

年卷期： 2020 年 109 卷

页码：

收录情况： SCI

摘要： This study explored the preventive effects of polysaccharide extracted from Gracilaria Lemaneiformis in mice with colitis induced by dextran sulfate sodium (DSS). FT-IR spectrum showed that SP was a typical sulfated polysaccharide (SP), which contained high content of S element in energy dispersive spectrometer (EDS) analysis. SP was mainly composed of (1 -> 3)-linked glycosidic bonds. Our results showed that SP could improve physical conditions of mice via alleviating weight loss and appetite suppression. Besides, SP could decrease the content of endotoxin (ET), lipopolysaccharide binding protein (LBP) and the activity of myeloperoxidase in serum. Meanwhile, SP also suppressed the secretion of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-1 beta (IL-1 beta) in colon tissue. These indicators showed that SP had ameliorated colitis symptoms. Furthermore, histological analysis indicated that SP could maintain healthy colonic microstructure including crypt, goblet cell and mucosal muscularis. Meanwhile, immunohistochemical results showed that tight junction proteins, including Claudin-1, ZO-1, and mucin (MUC-2) were promoted in colon with SP treatment. In conclusion, SP could enhance intestinal barrier, protect colonic microstructure and attenuate DSS-induced colonic injuries in mice, which suggested that SP could be a potentially functional component against colitis.

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