Dietary calcium deficiency suppresses follicle selection in laying ducks through mechanism involving cyclic adenosine monophosphate-mediated signaling pathway
文献类型： 外文期刊
作者： Chen, W. 1 ; Xia, W. G. 1 ; Ruan, D. 1 ; Wang, S. 1 ; Abouelezz, K. F. M. 1 ; Wang, S. L. 1 ; Zhang, Y. N. 1 ; Zheng, C. 1 ;
作者机构： 1.Guangdong Acad Agr Sci, Inst Anim Sci, Guangzhou 510640, Peoples R China
2.State Key Lab Livestock & Poultry Breeding, Guangzhou 510640, Peoples R China
3.Minist Agr & Rural Affairs, Key Lab Anim Nutr & Feed Sci South China, Guangzhou 510640, Peoples R China
4.Guangdong Publ Lab Anim Breeding & Nutr, Guangzhou 510640, Peoples R China
5.Guangdong Key Lab Anim Breeding & Nutr, Guangzhou 510640, Peoples R China
6.Assiut Univ, Dept Poultry Prod, Fac Agr, Assiut 71526, Egypt
关键词： hierarchical follicles; gonadotrophic hormones; granulosa cell; protein kinase A; extracellular signal-regulated kinase
期刊名称：ANIMAL （ 影响因子：3.24； 五年影响因子：3.223 ）
ISSN： 1751-7311
年卷期： 2020 年 14 卷 10 期
页码：
收录情况： SCI
摘要： Ovarian follicle selection is a natural biological process in the pre-ovulatory hierarchy in birds that drives growing follicles to be selected within the ovulatory cycle. Follicle selection in birds is strictly regulated, involving signaling pathways mediated by dietary nutrients, gonadotrophic hormones and paracrine factors. This study aimed to test the hypothesis that dietary Ca may participate in regulating follicle selection in laying ducks through activating the signaling pathway of cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA)/extracellular signal-regulated kinase (ERK), possibly mediated by gonadotrophic hormones. Female ducks at 22 weeks of age were initially fed one of two Ca-deficient diets (containing 1.8% or 0.38% Ca) or a Ca-adequate control diet (containing 3.6% Ca) for 67 days (depletion period), then all birds were fed the Ca-adequate diet for an additional 67 days (repletion period). Compared with the Ca-adequate control, ducks fed 0.38% Ca during the depletion period had significantly decreased (P< 0.05) numbers of hierarchical follicles and total ovarian weight, which were accompanied by reduced egg production. Plasma concentration of FSH was decreased by the diet containing 1.8% Ca but not by that containing 0.38%. The ovarian content of cAMP was increased with the two Ca-deficient diets, and phosphorylation of PKA and ERK1/2 was increased with 0.38% dietary Ca. Transcripts of ovarianestradiol receptor 2andluteinizing hormone receptor(LHR) were reduced in the ducks fed the two Ca-deficient diets (P< 0.05), while those of the ovarianfollicle stimulating hormone receptor(FSHR) were decreased in the ducks fed 0.38% Ca. The transcript abundance of ovary gap junction proteins, A1 and A4, was reduced with the Ca-deficient diets (P< 0.05). The down-regulation of gene expression of gap junction proteins and hormone receptors, the increased cAMP content and the suppressed hierarchical follicle numbers were reversed by repletion of dietary Ca. These results indicate that dietary Ca deficiency negatively affects follicle selection of laying ducks, independent of FSH, but probably by activating cAMP/PKA/ERK1/2 signaling pathway.
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