文献类型： 外文期刊
作者： Mu, Xiyan 1 ; Liu, Jia 1 ; Yuan, Lilai 1 ; Huang, Ying 1 ; Qian, Le 2 ; Wang, Chengju 2 ;
作者机构： 1.Chinese Acad Fishery Sci, Fishery Resource & Environm Res Ctr, Beijing, Peoples R China
2.China Agr Univ, Coll Sci, Beijing, Peoples R China
关键词： Bisphenol analogs; Zebrafish; Depigmentation; Tyrosinase family; Ligand binding energetics
期刊名称：ENVIRONMENTAL POLLUTION （ 影响因子：8.071； 五年影响因子：8.35 ）
ISSN： 0269-7491
年卷期： 2020 年 266 卷
页码：
收录情况： SCI
摘要： Bisphenol A (BPA) and bisphenol F (BPF) are widely distributed in the environment and daily consumptions, leading to exposure toward human and environmental animals. The potential risk of bisphenol analogs on pigment and skin health is not well documented. In this study, we found that 0.05 mg/L BPF (tolerated daily intake (TDI) value of BPA) affected the particle size and color density of zebrafish melanin. While BPA caused less depigmentation effect toward zebrafish with effective concentration of 5.0 mg/L. The downregulation of melanin synthases induced by BPF is associated with the reduction in melanin. Molecular dynamics indicated that both BPF and BPA could act as ligands of zebrafish and human Tyr family proteins; however, these compounds have completely different energetics and spatial steric effects, potentially explaining their varying depigmentation effects. Additionally, an in vitro assay using A375 melanoma cells demonstrated that the inhibitory effect of BPF on human melanin production was primarily attributed to Tyr inhibition. These findings provide an important basis for understanding the molecular mechanisms of BPF and BPA in melanin inhibition, and the results reflect the skin pigmentation interference risk of these compounds, which are ubiquitous in everyday personal products. (C) 2020 Elsevier Ltd. All rights reserved.
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