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The plant protein NbP3IP directs degradation ofRice stripe virusp3 silencing suppressor protein to limit virus infection through interaction with the autophagy-related protein NbATG8

文献类型： 外文期刊

作者： Jiang, Liangliang 1 ; Lu, Yuwen 2 ; Zheng, Xiyin 4 ; Yang, Xue 5 ; Chen, Ying 5 ; Zhang, Tianhao 2 ; Zhao, Xing 5 ; Wang, 1 ;

作者机构： 1.Nanjing Agr Univ, Coll Plant Protect, Nanjing 210095, Peoples R China

2.Zhejiang Acad Agr Sci, State Key Lab Managing Biot & Chem Threats Qual &, Key Lab Biotechnol Plant Protect MOA & Zhejiang P, Hangzhou 310021, Peoples R China

3.Ningbo Univ, Inst Plant Virol, Ningbo 315211, Peoples R China

4.Tsinghua Univ, MOE Key Lab Bioinformat, Tsinghua Peking Ctr Life Sci, Ctr Plant Biol,Sch Life Sci, Beijing 100084, Peoples R China

5.Shenyang Agr Univ, Coll Plant Protect, Shenyang 110161, Peoples R China

6.Zhejiang Univ, Coll Agr & Biotechnol, Hangzhou 310058, Peoples R China

7.Zhejiang Acad Agr Sci, Publ Lab, Hangzhou 310021, Peoples R China

8.James Hutton Inst, Cell & Mol Sci Grp, Dundee DD2 5DA, Scotland

关键词： ATG8; autophagy; p3; P3IP; Rice stripe virus(RSV)

期刊名称：NEW PHYTOLOGIST （ 影响因子：10.151； 五年影响因子：10.475 ）

ISSN： 0028-646X

年卷期：

页码：

收录情况： SCI

摘要： In plants, autophagy is involved in responses to viral infection. However, the role of host factors in mediating autophagy to suppress viruses is poorly understood. A previously uncharacterized plant protein, NbP3IP, was shown to interact with p3, an RNA-silencing suppressor protein encoded byRice stripe virus(RSV), a negative-strand RNA virus. The potential roles of NbP3IP in RSV infection were examined. NbP3IP degraded p3 through the autophagy pathway, thereby affecting the silencing suppression activity of p3. Transgenic overexpression of NbP3IP conferred resistance to RSV infection inNicotiana benthamiana. RSV infection was promoted in ATG5- or ATG7-silenced plants and was inhibited in GAPC-silenced plants where autophagy was activated, confirming the role of autophagy in suppressing RSV infection. NbP3IP interacted with NbATG8f, indicating a potential selective autophagosomal cargo receptor role for P3IP. Additionally, the rice NbP3IP homolog (OsP3IP) also mediated p3 degradation and interacted with OsATG8b and p3. Through identification of the involvement of P3IP in the autophagy-mediated degradation of RSV p3, we reveal a new mechanism to antagonize the infection of RSV, and thereby provide the first evidence that autophagy can play an antiviral role against negative-strand RNA viruses.

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