您好，欢迎访问浙江省农业科学院 机构知识库！
浙江省农业科学院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Cynaroside regulates the AMPK/SIRT3/Nrf2 pathway to inhibit doxorubicin-induced cardiomyocyte pyroptosis

文献类型： 外文期刊

作者： Zou, Hai 1 ; Zhang, Mengyu 3 ; Yang, Xue 4 ; Shou, Huafeng 5 ; Chen, Zhenglin 6 ; Zhu, Quanfeng 6 ; Luo, Ting 7 ; Mou, Xiaozhou 4 ; Chen, Xiaoyi 4 ;

作者机构： 1.Fudan Univ, Shanghai Canc Ctr, Dept Crit Care Med, Shanghai 200032, Peoples R China

2.Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai 200032, Peoples R China

3.Xianghu Lab, Hangzhou 311231, Peoples R China

4.Hangzhou Med Coll, Clin Res Inst, Key Lab Tumor Mol Diag & Individualized Med Zhejia, Zhejiang Prov Peoples Hosp,Affiliated Peoples Hosp, Hangzhou 310014, Peoples R China

5.Hangzhou Med Coll, Ctr Reprod Med, Dept Gynecol, Zhejiang Prov Peoples Hosp,Affiliated Peoples Hosp, Hangzhou 310014, Peoples R China

6.Zhejiang Chinese Med Univ, Grad Sch, Hangzhou 310053, Peoples R China

7.Zhejiang Acad Agr Sci, Inst Agroprod Safety & Nutr, State Key Lab Managing Biot & Chem Threats Qual &, Lab Hangzhou Risk Assessment Agr Prod,Minist Agr, Hangzhou 310021, Peoples R China

8.Hangzhou Med Coll, Zhejiang Prov Peoples Hosp, Dept Hepatobiliary & Pancreat Surg & Minimally Inv, Gen Surg,Canc Ctr,Affiliated Peoples Hosp, Hangzhou 310014, Peoples R China

关键词： Cynaroside; Doxorubicin; Pyroptosis; Cardiotoxicity; Oxidative stress

期刊名称：JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B （ 影响因子：4.9； 五年影响因子：4.7 ）

ISSN： 1673-1581

年卷期： 2024 年 25 卷 9 期

页码：

收录情况： SCI

摘要： Doxorubicin (DOX) is a commonly administered chemotherapy drug for treating hematological malignancies and solid tumors; however, its clinical application is limited by significant cardiotoxicity. Cynaroside (Cyn) is a flavonoid glycoside distributed in honeysuckle, with confirmed potential biological functions in regulating inflammation, pyroptosis, and oxidative stress. Herein, the effects of Cyn were evaluated in a DOX-induced cardiotoxicity (DIC) mouse model, which was established by intraperitoneal injections of DOX (5 mg/kg) once a week for three weeks. The mice in the treatment group received dexrazoxane, MCC950, and Cyn every two days. Blood biochemistry, histopathology, immunohistochemistry, reverse transcription-quantitative polymerase chain reaction (RT-qPCR), and western blotting were conducted to investigate the cardioprotective effects and potential mechanisms of Cyn treatment. The results demonstrated the significant benefits of Cyn treatment in mitigating DIC; it could effectively alleviate oxidative stress to a certain extent, maintain the equilibrium of cell apoptosis, and enhance the cardiac function of mice. These effects were realized via regulating the transcription levels of pyroptosis-related genes, such as nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3), caspase-1, and gasdermin D (GSDMD). Mechanistically, for DOX-induced myocardial injury, Cyn could significantly modulate the expression of pivotal genes, including adenosine monophosphate-activated protein kinase (AMPK), peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1 alpha), sirtuin 3 (SIRT3), and nuclear factor erythroid 2-related factor 2 (Nrf2). We attribute it to the mediation of AMPK/SIRT3/Nrf2 pathway, which plays a central role in preventing DOX-induced cardiomyocyte injury. In conclusion, the present study confirms the therapeutic potential of Cyn in DIC by regulating the AMPK/SIRT3/Nrf2 pathway.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：浙江省农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台