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Molecular Pathways Involved in Promoting Activity of Timosaponin BII on Hair Growth in C57BL/6 Mice

文献类型： 外文期刊

作者： Xiao, Lei 1 ; Zhang, Xia 1 ; Chen, Zhiyi 3 ; Li, Jianhua 2 ; Li, Bing 1 ; Li, Lin 1 ;

作者机构： 1.South China Univ Technol, Guangdong Prov Key Lab Green Proc Nat Prod & Prod, Sch Food Sci & Engn, Guangzhou 510640, Peoples R China

2.Infinitus China Co, Hong Kong, Peoples R China

3.Guangdong Acad Agr Sci, Minist Agr & Rural Affairs, Guangdong Key Lab Agr Prod Proc, Sericultural & Agrifood Res Inst,Key Lab Funct Fo, Guangzhou 510610, Peoples R China

4.Dongguan Univ Technol, Sch Chem Engn & Energy Technol, Coll Rd 1, Dongguan 523808, Peoples R China

期刊名称：BIOMED RESEARCH INTERNATIONAL （ 影响因子：3.411； 五年影响因子：3.62 ）

ISSN： 2314-6133

年卷期： 2020 年 2020 卷

页码：

收录情况： SCI

摘要： Hair loss is a common disease in dermatology, while the approved drugs may have unpredictable side effects. In this study, the effect of timosaponin BII extracted fromAnemarrhena asphodeloideson hair growth of C57BL/6 mice was investigated by measuring the hair follicle morphology, hair growth length and area in C57BL/6 male mice, and the immunohistochemical analysis of beta-catenin, Wnt3a, and Wnt10b in the dorsal skins of mice after topical application with minoxidil and timosaponin BII for 15 days. The decrease in skin brightness, the increase in the regrowing area of hair and hair follicles numbers, and the improvement of hair follicle morphology in the group applied with 0.5% timosaponin BII indicated an induction of the anagen phase in telogenic mice skin, which were comparative to the 2% minoxidil treatment. The immunohistochemical analysis detected an increase in the expression of beta-catenin and Wnt10b, supporting the theory of the activation of the beta-catenin/Wnt pathway was one of the pathways that are related to anagen phase induction.Anemarrhena asphodeloidesis a herb commonly used for metabolic disorders in China. The present study is the first to show that the timosaponin BII, which is present at a high concentration inA. asphodeloides, promotes hair growth in C57BL/6 male mice. The results indicate that timosaponin BII may be a potential promoting agent for hair growth.

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