Analysis of the microRNA expression profiles of chicken dendritic cells in response to H9N2 avian influenza virus infection
文献类型： 外文期刊
作者： Yang, Jing 1 ; Huang, Xinmei 1 ; Liu, Yuzhuo 1 ; Zhao, Dongmin 1 ; Han, Kaikai 1 ; Zhang, Lijiao 1 ; Li, Yin 1 ; Liu, Qin 1 ;
作者机构： 1.Jiangsu Acad Agr Sci, Natl Ctr Engn Res Vet Bioprod, Inst Vet Med, Key Lab Vet Biol Engn & Technol,Minist Agr, 50 Zhongling St, Nanjing 210014, Jiangsu, Peoples R China
2.Jiangsu Univ, Zhenjiang, Jiangsu, Peoples R China
关键词： microRNA; chicken dendritic cell; pathogenesis; host defense response
期刊名称：VETERINARY RESEARCH （ 影响因子：3.683； 五年影响因子：4.106 ）
ISSN： 0928-4249
年卷期： 2020 年 51 卷 1 期
页码：
收录情况： SCI
摘要： MicroRNA (miRNA) plays a key role in virus-host interactions. Here, we employed deep sequencing technology to determine cellular miRNA expression profiles in chicken dendritic cells infected with H9N2 avian influenza virus (AIV). A total of 66 known and 36 novel miRNAs were differently expressed upon H9N2 infection, including 72 up-regulated and 30 down-regulated miRNAs. Functional analysis showed that the predicted targets of these miRNAs were significantly enriched in several pathways including endocytosis, notch, lysosome, p53, RIG-I-like and NOD-like receptor signaling pathways. These data provide valuable information for further investigating the roles of miRNA in AIV pathogenesis and host defense response.
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