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Antibody developments for metal ions and their applications

文献类型： 外文期刊

作者： Wang, Yulong 1 ; Zhang, Cunzheng 1 ; Liu, Fengquan 2 ;

作者机构： 1.Jiangsu Acad Agr Sci, Inst Food Safety & Nutr, Jiangsu Key Lab Food Qual & Safety, Minist Sci & Technol,State Key Lab Cultivat Base, Nanjing 210014, Peoples R China

2.Jiangsu Acad Agr Sci, Inst Plant Protect, Nanjing, Peoples R China

关键词： Metal ions; hapten; immunoassay; medical diagnosis and therapy; antibody

期刊名称：FOOD AND AGRICULTURAL IMMUNOLOGY （ 影响因子：3.101； 五年影响因子：2.573 ）

ISSN： 0954-0105

年卷期： 2020 年 31 卷 1 期

页码：

收录情况： SCI

摘要： Metal ions are beneficial or toxic in part depending on their identity, valence state, and concentration. Antibodies against radioactive metal ions can be used in medical diagnosis and therapy, while antibodies against heavy metal ions are widely used in the trace element analysis of the immunoassay. This review focuses on the recent advances in antibody developments for metal ions and their applications. We exhaustively enumerated 18 chelate or ligand structures for metal hapten synthesis, which were proven to produce antibodies that cover almost 33 metal ions. The binding properties of these antibodies for their corresponding haptens were also discussed both in the structural foundation and molecular foundation. Furthermore, the representative applications of the antibodies used in medical diagnostics and therapy, and immunoassays were summarized. Finally, we illustrated the present challenges in high specific metal ion antibody preparation, and in immunoassay development. The future perspectives were also discussed.

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