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Phenolic Acids-Rich Fractions from Agaricus bitorguis (Quel.) Sacc. Chaidam ZJU-CDMA-12 Mycelia Modulate Hypoxic Stress on Hypoxia-Damaged PC12 Cells

文献类型： 外文期刊

作者： Lu, Hongyun 1 ; Jiao, Zhihua 2 ; Jiao, Yingchun 3 ; Wang, Wei 4 ; Chen, Qihe 1 ;

作者机构： 1.Zhejiang Univ, Dept Food Sci & Nutr, Hangzhou 310058, Peoples R China

2.Johns Hopkins Univ, Sch Med, Dept Cell Biol, Baltimore, MD 21205 USA

3.Qinghai Univ, Agr & Anim Husb Coll, Xining 810016, Peoples R China

4.Zhejiang Acad Agr Sci, Inst Qual & Stand Agr Prod, Hangzhou 310021, Peoples R China

关键词： intracellular phenolic acids; Agaricus bitorquis (QueL.) Sacc; Chaidam; structure characterization; anti-hypoxia activity

期刊名称：MOLECULES （ 影响因子：4.411； 五年影响因子：4.587 ）

ISSN：

年卷期： 2020 年 25 卷 20 期

页码：

收录情况： SCI

摘要： Hypoxia is a common pathological process in various clinical diseases. However, there is still a lack of effective anti-hypoxia active substances. Agaricus bitorguis (Quel.) Sacc Chaidam (ABSC) is a rare wild edible macrofungus that grows underground at high altitudes. Herein, intracellular phenolic acids-rich fractions (IPA) were extracted from ABSC ZJU-CDMA-12, and the structural characterization and anti-hypoxia activity of IPA on PC12 cells were elucidated as well. The results of HPLC-Q-TOF-MS illustrated that five kinds of IPA were isolated from ABSC, including (-)-epicatechin gallate, arabelline, yunnaneic acid D, 2 '-O-p-hydroxybenzoyl-6 '-O-trans-caffeoylgardoside,4 '-O-methylgallocatechin-(4->8)-4 '-O-methylepigallocatechin. IPA extracted from ABSC proved to show anti-hypoxia activity on hypoxia-damaged PC12 cells. Hypoxia enhanced reactive oxygen species (ROS) generation and reduced the mitochondrial membrane potential (Delta psi m) in PC12 cells, resulting in the inhibition of survival and induction of apoptosis in PC12 cells. Measurements of 100 mu g/mL and 250 mu g/mL IPA could significantly reduce hypoxia-induced damage in PC12 cells by decreasing overproduced intracellular ROS, improving Delta psi m, and reducing cell apoptosis rate. Our findings indicated that the IPA from ABSC potentially could be used as novel bioactive components applied to anti-hypoxia functional foods or medicines.

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