Inhibition of biofilm formation and quorum sensing by soy isoflavones in Pseudomonas aeruginosa
文献类型： 外文期刊
作者： Yin, Liqing 1 ; Zhang, Yongzhu 3 ; Azi, Fidelis 2 ; Zhou, Jianzhong 1 ; Liu, Xiaoli 1 ; Dai, Yiqiang 1 ; Wang, Zhe 1 ; Dong, Mingsheng 2 ; Xia, Xiudong 1 ;
作者机构： 1.Jiangsu Acad Agr Sci, Inst Agr Prod Proc, 50 Zhongling St, Nanjing, Peoples R China
2.Nanjing Agr Univ, Coll Food Sci & Technol, 1 Weigang Rd, Nanjing 210095, Jiangsu, Peoples R China
3.Jiangsu Acad Agr Sci, Inst Food Safety & Nutr, 50 Zhongling St, Nanjing 210014, Jiangsu, Peoples R China
4.Jiangsu Univ, Sch Food & Biol Engn, 301 Xuefu Rd, Zhenjiang 212013, Jiangsu, Peoples R China
关键词： Violacein; Virulence factor; Acyl-homoserine lactone; Motility; Molecular docking
期刊名称：FOOD CONTROL （ 影响因子：6.652； 五年影响因子：6.498 ）
ISSN： 0956-7135
年卷期： 2022 年 133 卷
页码：
收录情况： SCI
摘要： The potential of soybean isoflavones (SI) as a quorum sensing (QS) inhibitor against Pseudomonas aeruginosa was investigated in the present study. The inhibitory effects of SI on violacein production, biofilm formation, motility, and virulence factor production were evaluated. The acyl-homoserine lactones (AHLs) were quantified by liquid chromatography-mass spectrometry (LC-MS). The QS-related genes were analyzed by qRT-PCR. The molecular docking analysis was employed to investigate the anti-QS mechanism of the SI. Results demonstrated that the SI exhibited significant inhibition (p < 0.05) in violacein production, biofilm formation, motility, virulence factors, AHLs production, and expression levels of QS-related genes in P. aeruginosa. Additionally, the result of molecular docking analysis revealed that SI had a promising competitive interaction with AHLs. Hence, the study provided a deep insight into SI as a QS inhibitor against P. aeruginosa.
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