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Glutamine protects intestinal immunity through microbial metabolites rather than microbiota

文献类型： 外文期刊

作者： Li, Shuai 1 ; Wen, Xiaolu 2 ; Yang, Xuefen 2 ; Wang, Li 2 ; Gao, Kaiguo 2 ; Liang, Xingwei 1 ; Xiao, Hao 2 ;

作者机构： 1.Guangxi Univ, Coll Anim Sci & Technol, State Key Lab Conservat & Utilizat Subtrop Agrobi, Nanning 530004, Peoples R China

2.Guangdong Acad Agr Sci, Inst Anim Sci,Guangdong Key Lab Anim Breeding & Nu, Maoming Branch,Guangdong Publ Lab Anim Breeding &, Minist Agr Key Lab Anim Nutr & Feed Sci South Chin, 1 Dafeng 1st St, Guangzhou 510640, Peoples R China

关键词： Glutamine; Metabolomics profiling; Intestinal microbiota; Intestinal immunity; Mice

期刊名称：INTERNATIONAL IMMUNOPHARMACOLOGY （ 影响因子：5.6； 五年影响因子：5.6 ）

ISSN： 1567-5769

年卷期： 2023 年 124 卷

页码：

收录情况： SCI

摘要： Glutamine has anti-inflammatory properties as well as the ability to maintain the integrity of the intestinal barrier. In our previous study, we found that 1.0% glutamine promoted SIgA (secretory immunoglobulin A) synthesis in the gut via both T cell-dependent and non-dependent processes, as well as via the intestinal microbiota. The purpose of this study was to investigate whether the intestinal microbiota or microbial metabolites regulate SIgA synthesis. In the mouse model, supplementation with 1.0% glutamine had no significant effect on the intestinal microbiota, but KEGG function prediction showed the difference on microbiota metabolites. Therefore, in this study, untargeted metabolomics techniques were used to detect and analyze the metabolic changes of glutamine in intestinal luminal contents. Metabolomics showed that in the positive ion (POS) mode, a total of 1446 metabolic differentials (VIP = 1, P < 0.05, FC = 2 or FC = 0.5) were annotated in samples treated with glutamine-supplemented group compared to control group, of which 922 were up-regulated and 524 down-regulated. In the negative ion (NEG) mode, 370 differential metabolites (VIP = 1, P < 0.05, FC = 2 or FC = 0.5) were screened, of which 220 were up-regulated and 150 down-regulated. These differential metabolites mainly include bile secretion synthesis, ABC transporters, diterpenoids and other secondary metabolites. KEGG analysis showed that propionic acid metabolism, TCA cycle, endoplasmic reticulum protein processing, nitrogen metabolism and other metabolic pathways were active. The above metabolic pathways and differential metabolites have positive effects on intestinal development and intestinal immunity, and combined with our previous studies, we conclude that glutamine supplementation can may maintain intestinal homeostasis and improving intestinal immunity through intestinal microbial metabolites.

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