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Developing Ganoderma lucidum as a next-generation cell factory for food and nutraceuticals

文献类型： 外文期刊

作者： Azi, Fidelis 1 ; Wang, Zhe 3 ; Chen, Wenhao 1 ; Lin, Dewei 1 ; Xu, Peng 1 ;

作者机构： 1.Guangdong Technion Israel Inst Technol GTIIT, Dept Chem Engn, Shantou 515063, Guangdong, Peoples R China

2.Technion Israel Inst Technol, IL-3200002 Haifa, Israel

3.Jiangsu Acad Agr Sci, Inst Agroprod Proc, Nanjing 210014, Peoples R China

4.GTIIT, Guangdong Prov Key Lab Mat & Technol Energy Conver, Shantou 515063, Guangdong, Peoples R China

期刊名称：TRENDS IN BIOTECHNOLOGY （ 影响因子：17.3； 五年影响因子：18.1 ）

ISSN： 0167-7799

年卷期： 2024 年 42 卷 2 期

页码：

收录情况： SCI

摘要： Ganoderma lucidum holds a colossal reservoir of hydrolytic enzymes and therapeutic compounds and can be a sustainable source of proteins and bioactive compounds. Its metabolic versatility, propelled by its rich genome content, provides excellent biosynthetic machinery for innovation-driven pathway engineering. However, robust regulatory networks and low frequency of homologous recombination are critical bottlenecks that limit the development of molecular tools and precise genetic markers for biomanufacturing innovations in this organism. Modern synthetic biology provides tools that could help to accelerate precise multiple gene targeting and editing and untangling the biosynthetic machinery of G. lucidum. This review provides insight into molecular strategies to unwind the regulatory bottlenecks and transform G. lucidum into efficient cell factories for food and nutraceuticals.

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