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Effect of dietary koumine on the immune and antioxidant status of carp (Cyprinus carpio) after Aeromonas hydrophila infection

文献类型： 外文期刊

作者： Wang, Qiujie 1 ; Sun, Di 1 ; Wang, Dongjie 1 ; Ye, Bin 1 ; Wang, Shaodan 2 ; Zhou, Aiguo 1 ; Dong, Zaijie 3 ; Zou, Jixing 1 ;

作者机构： 1.South China Agr Univ, Coll Marine Sci, Joint Lab Guangdong Prov & Hong Kong Reg Marine Bi, Guangzhou 510642, Peoples R China

2.Fujian Agr & Forestry Univ, Coll Marine Sci, Fuzhou 350002, Peoples R China

3.Chinese Acad Fishery Sci, Freshwater Fisheries Res Ctr, Key Lab Freshwater Fisheries & Germplasm Resources, Minist Agr & Rural Affairs, Wuxi 214081, Peoples R China

4.South China Agr Univ, Coll Marine Sci, 483 Wushan Rd, Wushan St, Guangzhou, Guangdong, Peoples R China

5.Chinese Acad Fishery Sci, Freshwater Fisheries Res Ctr, 9 Shanshui East Rd South, Wuxi, Jiangsu, Peoples R China

关键词： Koumine; Antioxidant capacity; Histopathology; Immune function

期刊名称：MICROBIAL PATHOGENESIS （ 影响因子：3.8； 五年影响因子：4.0 ）

ISSN： 0882-4010

年卷期： 2024 年 186 卷

页码：

收录情况： SCI

摘要： Koumine (KM) has anxiolytic, anti-inflammatory and growth-promoting effects in pigs and sheep. Based on the growth-promoting and immunological effects of koumine, the present study was conducted on Cyprinus carpio (C. carpio) with four KM concentrations: 0 mg/kg, 0.2 mg/kg, 2 mg/kg, and 20 mg/kg for 10 weeks, followed by a 1-week Aeromonas hydrophila (A. hydrophila) infection experiment. The effect of KM on the immunity of A. hydrophila infected carp was analyzed by histopathology, biochemical assay, and qRT-PCR to assess the feasibility of KM in aquaculture. The results showed that the presence of KM alleviated pathogen damage to carp tissues. At 2 mg/kg and 20 mg/kg concentrations of KM successively and significantly elevated (p < 0.05) the SOD activities in the intestinal tract, hepatopancreas and kidney of carp. The expression levels of hep-atopancreatic antioxidant genes Nrf2 and IGF-1 were significantly up-regulated in the same group (p < 0.05), while the expression levels of immune genes IL-8 and IL-10 were down-regulated. In summary, KM at concen-trations of 2 mg/kg and 20 mg/kg could regulate the expression of antioxidant and immune genes in various tissues in an orderly and rapid manner, and significantly improve the antioxidant and immune abilities of carp, which is conducive to the improvement of the resilience of carp.

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