文献类型： 外文期刊

作者： Davaatseren, Munkhtugs ¹ ; Hwang, Jin-Taek ¹ ; Park, Jae Ho ¹ ; Kim, Myung-Sunny ¹ ; Wang, Shuaiyu ³ ; Sung, Mi Jeo ¹ ;

作者机构： 1.Korea Food Res Inst, Res Div Emerging Innovat Technol, Seongnam Gyeonggi 463746, South Korea

2.Univ Sci & Technol, Taejon 305350, South Korea

3.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Qingdao 266071, Shandong, Peoples R China

期刊名称：MEDIATORS OF INFLAMMATION （ 影响因子：4.711； 五年影响因子：5.34 ）

ISSN： 0962-9351

年卷期： 2013 年

页码：

收录情况： SCI

摘要： Poly-gamma-glutamic acid (gamma-PGA), naturally secreted from various strains of Bacillus, has anti-inflammatory activity. In inflammatory bowel disease (IBD), inflammation is promoted and sustained by angiogenesis; however, the role played by gamma-PGA in this condition is unclear. Therefore, we evaluated gamma-PGA effects on angiogenesis and inflammation in a dextran sulfate sodium-(DSS-) induced mouse colitis model. Experimental colitis was induced in male C57BL/6 mice by administering 3% DSS. Disease activity index (DAI), histopathological scores, microvascular density, myeloperoxidase activity, and VEGF-A and VEGFR2 expression were compared among control mice, DSS-treated mice, and mice receiving 3% DSS along with gamma-PGA at 50 mg/kg body weight per day or 3% DSS with gamma-PGA at 200 mg/kg bodyweight per day. We found that gamma-PGA significantly attenuated weight loss, DAI, and colon shortening. gamma-PGA also significantly reduced histopathological evidence of injury. Moreover, gamma-PGA significantly attenuated DSS-induced blood vessel densities. Furthermore, gamma-PGA attenuated DSS-induced expression of VEGF-A and its receptor, VEGFR2. In addition, gamma-PGA treatment led to reduced recruitment of leukocytes to the inflamed colon. Therefore, our results indicate that gamma-PGA has potential application in conditions marked by inflammatory-driven angiogenesis and mucosal inflammation.