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Transcriptome and metabolome comprehensive analysis reveal the molecular basis of slow-action and non-repellency of cycloxaprid against an eusocial pest, Solenopsis invicta

文献类型： 外文期刊

作者： Du, Chengju 1 ; Jiang, Kaibin 2 ; Xu, Zhiping 3 ; Wang, Lei 4 ; Chen, Jie 5 ; Wang, Cai 1 ;

作者机构： 1.South China Agr Univ, Coll Forestry & Landscape Architecture, Guangzhou, Peoples R China

2.Guangdong Acad Forestry, Guangdong Prov Key Lab Silviculture Protect & Util, Guangzhou, Peoples R China

3.East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai, Peoples R China

4.South China Agr Univ, Coll Plant Protect, Guangzhou, Peoples R China

5.Guangdong Acad Agr Sci, Inst Plant Protect, Guangdong Prov Key Lab High Technol Plant Protect, Guangzhou, Peoples R China

关键词： eusocial insect; formicidae; red imported fire ant; neonicotinoid insecticide; cycloxaprid

期刊名称：FRONTIERS IN PHYSIOLOGY （ 影响因子：4.0； 五年影响因子：4.7 ）

ISSN：

年卷期： 2023 年 14 卷

页码：

收录情况： SCI

摘要： The eusocial pest, red imported fire ant (Solenopsis invicta), is a highly invasive species that poses significant threats to public safety, agriculture, and the ecological environment. Cycloxaprid, a newly identified effective, slow-acting, and non-repellent insecticide against S. invicta, allows contaminated individuals to transfer the insecticide among nestmates through body contact. However, the molecular-level changes occurring in S. invicta post cycloxaprid exposure and any molecular alterations contributing to the slow demise or decreased sensitivity remain unclear. In this study, transcriptomic and metabolomic techniques were used to investigate the molecular mechanisms of S. invicta exposed to cycloxaprid. Differential analysis results revealed 275, 323, and 536 differentially expressed genes at 12, 24, and 48 h, respectively. Genes involved in lipid and energy metabolism, DNA integration, and hormone synthesis were largely upregulated at 12 h, suggesting S. invicta might actively resist cycloxaprid impacts, and predominantly downregulated at 48 h, indicating further functional impairment and impending death. Also, we observed an imbalance in olfactory perception pathways at 12 h, which may indicate a disruption in the olfactory system of S. invicta. Metabolomic results showed that the regulation of most differential metabolites (DMs) was consistent with the expression changes of their related DEGs at different time points. Our study provides insights into the mechanism underlying slow-acting and non-repellent properties of cycloxaprid against S. invicta.

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