Effects of New Mutations in BMPRIB, GDF9, BMP15, LEPR, and B4GALNT2 Genes on Litter Size in Sheep
文献类型： 外文期刊
作者： Ji, Xuewen 1 ; Cao, Ziwei 2 ; Hao, Qi 1 ; He, Mei 2 ; Cang, Ming 1 ; Yu, Haiquan 1 ; Ma, Qing 3 ; Li, Xihe 1 ; Bao, Siqin 1 ; Wang, Jianguo 1 ; Tong, Bin 1 ;
作者机构： 1.Inner Mongolia Univ, Sch Life Sci, State Key Lab Reprod Regulat & Breeding Grassland, Hohhot 010070, Peoples R China
2.Xilingol Mengzhiyuan Anim Husb Co, Xilingol 026000, Peoples R China
3.Ningxia Acad Agr & Forestry Sci, Inst Anim Sci, Yinchuan 750001, Peoples R China
关键词： BMP15; BMPR1B; B4GALNT2; GDF9; LEPR; litter size; sheep
期刊名称：VETERINARY SCIENCES （ 影响因子：2.4； ）
ISSN：
年卷期： 2023 年 10 卷 4 期
页码：
收录情况： SCI
摘要： Prolificacy is a crucial characteristic of livestock, particularly for species such as sheep that have many births. The objectives of this study were as follows: (1) to investigate the genetic diversity of the 13 new and 7 known variants in the BMPRIB, GDF9, BMP15, LEPR, and B4GALNT2 genes in Ujimqin (UM), the F1 population of Dorper x Ujimqin crossbred (DPU), the F1 population of Suffolk x Ujimqin crossbred (SFKU), Sonid sheep (SN), Tan sheep (Tan), Hu sheep (Hu), and Small-tailed Han sheep (STH) sheep breeds/populations; (2) to perform an association analysis of the above 20 variants with litter size in 325 UM, 304 DPU, and 66 SFKU sheep populations; (3) to compare the frequencies of the litter-size-related alleles of these 20 variants among 8 sheep breeds/populations (the above seven sheep breeds + Mongolia sheep breed). With the use of the Sequenom MassARRAY (R) SNP assay technology, these 20 mutations were genotyped. The association analysis results showed that the c.746A>G (FecB) mutation in BMPR1B was significantly associated with the litter size of UM and DPU, the c.994A>G (FecG(A)) in GDF9 was significantly associated with the litter size of SFKU, and the c.31_33CTTinsdel (B1) in BMP15 was significantly associated with the litter size of UM. Our findings might provide valuable genetic markers for expanding sheep litter sizes.
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