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Effect of Silkworm Pupa Protein Hydrolysates on Proliferation of Gastric Cancer Cells In Vitro

文献类型： 外文期刊

作者： Li, Weixin 1 ; Mu, Lixia 1 ; Zou, Yuxiao 1 ; Wang, Weifei 1 ; Zhao, Haifeng 2 ; Wu, Xuli 3 ; Liao, Sentai 1 ;

作者机构： 1.Guangdong Acad Agr Sci, Minist Agr, Sericultural & Agrifood Res Inst, Guangdong Key Lab Agr Prod Proc,Key Lab Funct Foo, Guangzhou 510610, Peoples R China

2.South China Univ Technol, Sch Food Sci & Engn, Guangzhou 510640, Peoples R China

3.Shenzhen Univ, Hlth Sci Ctr, Sch Publ Hlth, Shenzhen 518060, Peoples R China

关键词： silkworm pupa protein hydrolysates; proliferation inhibition; morphological observation; apoptosis and cycle

期刊名称：FOODS （ 影响因子：5.561； 五年影响因子：5.94 ）

ISSN：

年卷期： 2022 年 11 卷 15 期

页码：

收录情况： SCI

摘要： The proliferation inhibition effects of the hydrolysates from silkworm pupa proteins on MGC-803 gastric cancer cells were investigated in this study. The specific morphological changes (cell membrane, cell nucleus and cytoskeleton) of cells were measured. In vitro, the proliferation of MGC-803 cells was inhibited by silkworm pupa protein hydrolysates (SPPHs) in a dose-dependent manner. The flow cytometry analysis showed that the blocking effect of SPPHs on the MGC-803 cells was mainly in the G(0)/G(1)-phase. The morphological changes, disintegration of the cytoskeleton and retardant cell cycles were probably related to the activation of apoptosis. Thus, SPPHs could be promising as a chemopreventive agent due to their ability to promote apoptosis of tumor cells.

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