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An inactivated PDCoV vaccine induces robust neutralizing antibodies and immune protection in pigs lasting for three months

文献类型： 外文期刊

作者： Fan, Liyuan 1 ; Wang, Wei 1 ; Yi, Xin 1 ; Yuan, Xuesong 1 ; Chen, Zhuoqi 1 ; Xiao, Li 1 ; Lu, Chunyu 1 ; Guo, Rongli 1 ; Fan, Baochao 1 ; Ma, Jiale 3 ; Zha, Yinhe 5 ; Shu, Jianhong 5 ; Li, Jizong 1 ; Li, Bin 1 ;

作者机构： 1.Jiangsu Acad Agr Sci, Inst Vet Med, Jiangsu Key Lab Food Qual & Safety,Key Lab Vet Bio, State Key Lab Cultivat Base,Minist Sci & Technol, Nanjing 210014, Peoples R China

2.Jiangsu Univ, Inst Life Sci, Sch Food & Biol Engn, Zhenjiang 212013, Peoples R China

3.Nanjing Agr Univ, Coll Vet Med, Nanjing 210095, Peoples R China

4.Yangzhou Univ, Jiangsu Coinnovat Ctr Prevent & Control Important, Yangzhou 225009, Peoples R China

5.Zhejiang Hongsheng Biotechnol CO LTD, Shaoxing 312000, Peoples R China

6.Jiangsu Acad Agr Sci, Inst Vet Med, Nanjing 210014, Peoples R China

关键词： Porcine deltacoronavirus; Pathogenicity; Inactivated PDCoV vaccine; Protection efficacy; Three-month-old pigs

期刊名称：MICROBIAL PATHOGENESIS （ 影响因子：3.3； 五年影响因子：3.6 ）

ISSN： 0882-4010

年卷期： 2024 年 192 卷

页码：

收录情况： SCI

摘要： Porcine deltacoronavirus (PDCoV), a novel enteropathogenic coronavirus, causes diarrhea mainly in suckling piglets and has the potential to infect humans. Whereas, there is no commercially available vaccine which can effectively prevent this disease. In this study, to ascertain the duration of immune protection of inactivated PDCoV vaccine, suckling piglets were injected subcutaneously with inactivated PDCoV vaccine using a prime/ boost strategy at 3 and 17-day-old. Neutralizing antibody assay showed that the level of the inactivated PDCoV group was still >= 1:64 at three months after prime vaccination. The three-month-old pigs were orally challenged with PDCoV strain CZ2020. Two pigs in challenge control group showed mild to severe diarrhea at 10-11 daypost-challenge (DPC), while the inactivated PDCoV group had no diarrhea. High levels of viral shedding, substantial intestinal villus atrophy, and positive straining of viral antigens in ileum were detected in challenge control group, while the pigs in inactivated PDCoV group exhibited significantly reduced viral load, minor intestinal villi damage and negative straining of viral antigens. These results demonstrated that PDCoV was pathogenic against three-month-old pigs and inactivated PDCoV vaccine can provide effective protection in pigs lasting for three months.

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